Altered Neural Cholinergic Receptor Systems in Cocaine-Addicted Subjects
Altered Neural Cholinergic Receptor Systems in Cocaine-Addicted Subjects
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DOI：
10.1038/npp.2010.18
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发表时间：
2010-06-01
影响因子：
7.6
通讯作者：
Cullum, Munro
中科院分区：
文献类型：
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作者：
Adinoff, Bryon;Devous, Michael D., Sr.;Cullum, Munro
大脑胆碱能受体系统的变化是几种神经精神疾病的基础，包括阿尔茨海默病、精神分裂症和抑郁症。一项新的临床前文献也揭示了乙酰可卡因在成瘾过程中可能有重要的作用，包括奖赏、学习和记忆。这项研究旨在评估与健康对照组相比，戒断性可卡因成瘾者边缘区域胆碱能受体系统的变化。在三个不同的天，23名戒断1-6周的可卡因(主要是尼古丁)成瘾的受试者和22名性别、年龄和种族匹配的对照组受试者接受毒扁豆碱和尼古丁胆碱能激动剂毒扁豆碱、毒扁豆碱拮抗剂东莨菪碱和生理盐水的治疗。单光子发射计算机断层扫描测定每次输液后局部脑血流量(RCBF)。两种胆碱能探针均可引起rCBF改变(p
Changes in the brain's cholinergic receptor systems underlie several neuropsychiatric disorders, including Alzheimer's disease, schizophrenia, and depression. An emerging preclinical literature also reveals that acetylcoholine may have an important function in addictive processes, including reward, learning, and memory. This study was designed to assess alterations in cholinergic receptor systems in limbic regions of abstinent cocaine-addicted subjects compared with healthy controls. On three separate days, 23 1- to 6-week abstinent, cocaine- ( and mostly nicotine-) addicted subjects and 22 sex-, age-, and race-matched control subjects were administered the muscarinic and nicotinic cholinergic agonist physostigmine, the muscarinic antagonist scopolamine, and saline. Regional cerebral blood flow (rCBF) after each infusion was determined using single photon emission-computed tomography. Both cholinergic probes induced rCBF changes (p