Study of the efficacy of melatonin for auditory brainstem response (ABR) testing in children.
Study of the efficacy of melatonin for auditory brainstem response (ABR) testing in children.
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褪黑激素对儿童听觉脑干反应（ABR）测试的功效研究。
DOI：
10.1016/j.anorl.2017.03.006
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
M. Mondain
中科院分区：
文献类型：
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作者：
L. Casteil;A. Viquesnel;V. Favier;N. Guignard;C. Blanchet;M. Mondain
研究目的通过计算口服褪黑素诱导睡眠的儿童的成功率，以及完成ABR测试所需的时间，来评价口服褪黑素诱导镇静(自然睡眠)的效果，同时测量可疑听力损失儿童的听性脑干反应(ABR)。材料和方法29名1~6岁的儿童参加这项前瞻性研究。ABR测试是在一个单独的房间里进行的日间检查，以确保合适的睡眠条件。在电极放置之前，口服5毫克褪黑素(或6岁以上儿童为10毫克)。结果用褪黑素进行ABR检查58耳，其中双耳ABR检查19耳(65%)，对应38次检查；单耳测试7耳(24.2%)，对应7次检查；3耳ABR检查失败3耳(10.3%)。17名儿童(59%)获得了良好的睡眠，4名儿童(14%)获得了短暂的睡眠，但在整个检查过程中仍保持平静，8名儿童(27%)没有入睡。服用褪黑素后的平均入睡时间为41分钟，平均睡眠时间为33分钟，首次服用褪黑素后的平均检查时间为52分钟。因此，一次完整的检查平均需要93分钟。结论在90%的儿童中，使用褪黑素可以进行部分或完全的ABR测试。这种方法是有效的，但它需要适应的设施来接收孩子和孩子的父母。
Study objectiveTo evaluate the efficacy of oral melatonin to induce sedation (natural sleep) while measuring auditory brainstem responses (ABR) in children with suspected hearing loss by calculating the ABR success rate with the use of melatonin, the percentage of children in whom sleep was induced by melatonin and the time required to perform complete ABR testing.Material and methodsTwenty-nine children aged 1 to 6 years were included in this prospective study. ABR testing was performed as a day-case procedure in a single room ensuring suitable sleeping conditions. Five milligrams of melatonin (or 10 mg in children over the age of 6 years) were administered orally before electrode positioning. An additional 5 milligrams were administered if the child failed to sleep after 30 minutes.ResultsABR was performed with melatonin in 58 ears: complete ABR testing was performed in both ears in 19 children (65%), corresponding to 38 examinations; only one ear was tested in 7 children (24.2%), corresponding to 7 examinations; and ABR testing could not be performed in 3 children (10.3% failure rate). Good quality sleep was obtained in 17 children (59%), brief sleep was obtained in 4 children (14%), who nevertheless remained calm throughout the examination and 8 children (27%) did not fall asleep. The mean sleep-onset time after administration of melatonin was 41 minutes with a mean sleep time of 33 minutes and a mean examination time of 52 minutes after the first dose of melatonin. A complete examination therefore took an average of 93 minutes.ConclusionThe use of melatonin allowed partial or complete ABR testing in 90% of children. This method is effective, but it requires adapted facilities to receive the child and the child's parents.