Perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure sensitizes offspring to angiotensin II-induced hypertension.
Perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure sensitizes offspring to angiotensin II-induced hypertension.
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DOI：
10.1007/s12012-008-9023-1
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发表时间：
2008
影响因子：
3.2
通讯作者：
Walker MK
中科院分区：
文献类型：
--
作者：
Aragon AC;Goens MB;Carbett E;Walker MK
In utero and lactational exposure of mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to cardiac hypertrophy and hydronephrosis in adulthood. We tested the hypothesis that perinatal TCDD exposure increases the susceptibility to cardiovascular disease when offspring are exposed to a common cardiovascular disease risk factor, angiotensin II (Ang II). Pregnant C57BL/6N mice were exposed to corn oil (control) or 6.0 µg/kg TCDD on gestation day 14.5. Male offspring were then exposed to a subpressor (0.1 mg/kg/d) or pressor (0.7 mg/kg/d) dose of Ang II at 3.5 mo and cardiac morphology and blood pressure analyzed, respectively. Perinatal TCDD exposure increased left ventricular cavity dilation during diastole, and wall thickness during diastole and systole. While Ang II stimulated an increase in wall thickness, the degree of increase was equivalent between control and TCDD offspring. In contrast, perinatal TCDD exposure did not alter basal blood pressure. However, Ang II increased systolic blood pressure more rapidly and to a greater degree in TCDD offspring. Further, Ang II stimulated renal myofibroblast differentiation and collagen deposition to a greater degree, and tended to increase procollagen I mRNA in TCDD offspring, compared to controls. These data suggest that perinatal TCDD exposure increases the susceptibility of offspring to renal fibrosis and hypertension in adulthood.
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影响因子：
3.8
作者：
COUTUREHAWS, L;HARRIS, MW;BIRNBAUM, LS
通讯作者：
BIRNBAUM, LS
影响因子：
10.4
作者：
Osmond C;Barker DJ
通讯作者：
Barker DJ
DOI：
10.1016/0272-0590(90)90171-f
发表时间：
1990-07-01
期刊：
FUNDAMENTAL AND APPLIED TOXICOLOGY
影响因子：
--
作者：
COUTURE, LA;HARRIS, MW;BIRNBAUM, LS
通讯作者：
BIRNBAUM, LS
DOI：
10.1002/tera.1420350308
发表时间：
1987-06-01
期刊：
TERATOLOGY
影响因子：
--
作者：
ABBOTT, BD;MORGAN, KS;PRATT, RM
通讯作者：
PRATT, RM
影响因子：
2.1
作者：
Ayan, S;Roth, JA;Peters, CA
通讯作者：
Peters, CA