Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography.
Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography.
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DOI：
10.1021/acs.bioconjchem.7b00194
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发表时间：
2017-06-21
影响因子：
4.7
通讯作者：
Cormode DP
中科院分区：
文献类型：
--
作者：
Kim J;Chhour P;Hsu J;Litt HI;Ferrari VA;Popovtzer R;Cormode DP
开发新的基于细胞的疗法的努力起源于1956年对白血病患者的第一次骨髓移植。基于细胞的治疗策略的临床前和临床实例已经在医学的许多学科中显示出有希望的结果，最近在癌症免疫细胞疗法方面的进展产生了显着的反应率，即使在多次治疗失败的患者中也是如此。然而，基于细胞的疗法遭受不一致的结果，激发了对允许在体内监测细胞递送和行为的工具的搜索。非侵入性细胞成像技术，也称为细胞跟踪，已被开发来解决这个问题。这些工具可以实时，定量和长期监测受体中的移植细胞，提供有关细胞迁移，分布，活力，分化和命运的见解，所有这些都在治疗效果中发挥关键作用。了解这些参数可以优化细胞选择，递送途径和治疗剂量，并推进基于细胞的治疗用于特定的临床用途。迄今为止，大多数细胞跟踪工作集中在成像方式，如MRI，放射性核素成像和光学成像。然而，X射线计算机断层扫描（CT）是一种新兴的细胞跟踪方法，具有几个优点，如高空间和时间分辨率，以及出色的定量能力。CT用于细胞追踪的优势因其广泛的可用性和成本效益而得到增强，使CT成为最流行的临床成像方式之一和疾病诊断的关键资产。在这篇综述中，我们将讨论最近的进展，在细胞跟踪方法使用X射线CT在各种应用中，除了预测该领域将如何发展。
Efforts to develop novel cell-based therapies originated with the first bone marrow transplant on a leukemia patient in 1956. Preclinical and clinical examples of cell-based treatment strategies have shown promising results across many disciplines in medicine, with recent advances in immune cell therapies for cancer producing remarkable response rates, even in patients with multiple treatment failures. However, cell-based therapies suffer from inconsistent outcomes, motivating the search for tools that allow monitoring of cell delivery and behavior in vivo. Noninvasive cell imaging techniques, also known as cell tracking, have been developed to address this issue. These tools can allow real-time, quantitative, and long-term monitoring of transplanted cells in the recipient, providing insight on cell migration, distribution, viability, differentiation, and fate, all of which play crucial roles in treatment efficacy. Understanding these parameters allows the optimization of cell choice, delivery route, and dosage for therapy and advances cell-based therapy for specific clinical uses. To date, most cell tracking work has centered on imaging modalities such as MRI, radionuclide imaging, and optical imaging. However, X-ray computed tomography (CT) is an emerging method for cell tracking that has several strengths such as high spatial and temporal resolution, and excellent quantitative capabilities. The advantages of CT for cell tracking are enhanced by its wide availability and cost effectiveness, allowing CT to become one of the most popular clinical imaging modalities and a key asset in disease diagnosis. In this review, we will discuss recent advances in cell tracking methods using X-ray CT in various applications, in addition to predictions on how the field will progress.