Galectin-3 expression in colorectal cancer: relation to invasion and metastasis.
Galectin-3 expression in colorectal cancer: relation to invasion and metastasis.
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发表时间：
2007-07
影响因子：
2
通讯作者：
Kaori Tsuboi;T. Shimura;N. Masuda;M. Ide;S. Tsutsumi;S. Yamaguchi;T. Asao;H. Kuwano
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作者：
Kaori Tsuboi;T. Shimura;N. Masuda;M. Ide;S. Tsutsumi;S. Yamaguchi;T. Asao;H. Kuwano
半乳糖凝集素-3（Galectin-3）是一种β-半乳糖苷结合蛋白，与细胞粘附、识别、增殖、分化和凋亡等多种生物学过程相关。本研究的目的是确定半乳糖凝集素-3表达与结直肠癌患者临床病理结果的关系。此外，半乳糖凝集素-3和β-连环蛋白的表达，Ki-67标记指数之间的相关性进行了研究。材料与方法对108例结直肠癌患者的标本进行半乳糖凝集素-3、β-连环蛋白和Ki-67表达的免疫组织化学评估。将galectin-3的表达分为肿瘤表面和浸润前沿，并从统计学角度考虑其与临床病理因素的关系。结果当galectin-3在肿瘤浸润前沿的表达低于其表面时，存在显著的肝转移（p = 0.04）。β-连环蛋白在肿瘤表面的表达与肝转移和肿瘤分期之间也存在显著相关性（分别为p = 0.03，p = 0.04）。结论galectin-3表达降低与大肠癌的侵袭转移有关。Galectin-3的表达可能参与了大肠癌患者的肿瘤侵袭、转移和增殖。
BACKGROUND Galectin-3, a beta-galactoside-binding protein, has been associated with various biological processes, such as cell adhesion, recognition, proliferation, differentiation and apoptosis. The aim of this study was to determine the relationship of galectin-3 expression to clinicopathological findings in patients with colorectal cancer. Furthermore, the correlation between the expression of galectin-3 and beta-catenin, and the Ki-67 labeling index were investigated. MATERIALS AND METHODS Immunohistochemical assessment of galectin-3, beta-catenin and Ki-67 expression was performed on samples from 108 patients with colorectal cancer. The expression of galectin-3 was classified at the tumor surface and the invasive front, and its relationship with clinicopathological factors was considered from a statistical viewpoint. RESULTS There was significant liver metastasis when the expression of galectin-3 was lower at the invasive front of a tumor compared to its surface (p = 0.04). There were also significant correlations between beta-catenin expression at the tumor surface and liver metastasis and tumor stage (p = 0.03, p = 0.04 respectively). CONCLUSION The reduction of galectin-3 expression is associated with the invasion and metastasis of colorectal cancer. A possible involvement of galectin-3 expression in tumor invasion, metastasis and proliferation in patients with colorectal cancer is suggested.