Role of Angiogenic and Inflammatory Signal Pathways in Psoriasis.
Role of Angiogenic and Inflammatory Signal Pathways in Psoriasis.
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DOI：
10.1038/jidsymp.2015.22
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
X. Man;M. Zheng
中科院分区：
文献类型：
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作者：
X. Man;M. Zheng
参与炎症反应的任何因子的失调在疾病的发展中是重要的，并且不能解决这种反应导致慢性炎症。银屑病是一种常见的免疫介导的慢性炎性皮肤病，其特征在于表皮增生、角化不全、真皮炎性细胞浸润和血管生成（Nestle等人，2009年）。在银屑病的表皮颗粒层和皮质层中，角质形成细胞的生长增加和分化改变（Perera等人，2012年）。
Dysregulation of any of the factors involved in the inflammatory response is important in the development of disease, and failure to resolve this response leads to chronic inflammation. Psoriasis is a common immune-mediated chronic inflammatory skin disease characterized by epidermal hyperplasia, parakeratosis, dermal inflammatory cell infiltration, and angiogenesis (Nestle et al., 2009). There is increased growth and altered differentiation of keratinocytes in both the epidermal granular and cornified layers in psoriasis (Perera et al., 2012).