RAI2: Linking Retinoic Acid Signaling with Metastasis Suppression.
RAI2: Linking Retinoic Acid Signaling with Metastasis Suppression.
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DOI：
10.1158/2159-8290.cd-15-0352
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发表时间：
2015-05
期刊：
影响因子：
28.2
通讯作者：
Kang Y
中科院分区：
文献类型：
--
作者：
Esposito M;Kang Y
大量证据表明弥散性肿瘤细胞（dtc）在预测乳腺癌临床结果中的重要性，dtc通常在骨髓中检测到，并表现出细胞可塑性的特征。在这一期的《癌症发现》杂志上，Werner及其同事报道了维甲酸诱导的2 （RAI2）作为一种抑制雌激素受体阳性乳腺癌早期转移扩散的分化因子的发现。
Considerable evidence points to the importance of disseminated tumor cells (DTCs), which are commonly detected in the bone marrow and display features of cellular plasticity, in predicting the clinical outcome of breast cancer. In this issue of Cancer Discovery, Werner and colleagues report on the discovery of retinoic acid-induced 2 (RAI2) as a differentiation factor that suppresses early metastatic spread of estrogen receptor positive breast cancer.