Time Course of Blood Parameters in Printing Workers with Cholangiocarcinoma
Time Course of Blood Parameters in Printing Workers with Cholangiocarcinoma
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DOI：
10.1539/joh.13-0263-oa
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发表时间：
2014-07-01
影响因子：
3
通讯作者：
Ichihara, Gaku
中科院分区：
文献类型：
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作者：
Kumagai, Shinji;Kurumatani, Norio;Ichihara, Gaku
目的：我们先前报告了一群长期接触1，2-二氯苯酚的打样工人中的胆管癌患者。方法：对10例胆管癌患者在职期间和退休后的健康体检记录进行统计分析。对患者和/或其亲属进行生活方式和职业史的访谈。结果：所有研究患者均接触1，2-二氯苯酚6~17年。几乎所有患者的红细胞、血红蛋白、红细胞压积、总胆固醇、甘油三酯和空腹血糖都在标准范围内，但有6名患者的伽马-谷氨酰转肽酶(γ-GTP)水平在1，2-DCP暴露期间超过标准范围。6名患者中有2名在接触1，2-DCP期间被诊断为胆管癌，另外4名患者在停止接触1-9年后被诊断为胆管癌。其余4名患者在1，2-DCP暴露期间伽马-GTP水平在标准范围内，但此后伽马-GTP水平升高，并在停止暴露4-10年后被诊断为胆管癌。天冬氨酸氨基转移酶和丙氨酸氨基转移酶水平随着γ-GTP水平的升高而开始升高。结论：1，2-二氯苯酚作业工人在接触过程中和接触后应定期进行健康检查。在检查中，即使是伽马-GTP水平的轻微升高也应被认为是胆管癌早期发展的信号。
Objectives: We previously reported a cluster of cholangiocarcinoma patients among proof-printing workers who were exposed to 1,2-DCP for a long term. The present study was conducted to evaluate blood parameters in these proof-printing workers during and after exposure.Methods: Health examination records during employment and after retirement were obtained for ten cholangiocarcinonna patients to analyze their blood parameters. The patients and/or their relatives were also interviewed about lifestyle and occupational history.Results: All study patients were exposed to 1,2-DCP for 6-17 years. Red blood cells, hemoglobin, hematocrit, total cholesterol, triglycerides, and fasting plasma glucose were within the standard ranges for almost all patients, but the gamma-glutamyl transpeptidase (gamma-GTP) levels exceeded the standard range during 1,2-DCP exposure for six patients. Two of the six patients were diagnosed with cholangiocarcinoma during 1,2-DCP exposure, and the other four patients were diagnosed 1-9 years after termination of exposure. The remaining four patients had gamma-GTP levels within the standard range during 1,2-DCP exposure, but had increased gamma-GTP levels thereafter, and were diagnosed with cholangiocarcinoma 4-10 years after termination of exposure. Aspartate aminotransferase and alanine aminotransferase levels started to increase following the increase in gamma-GTP levels.Conclusions: Workers exposed to 1,2-DCP should be provided with periodic health examinations during and after exposure. In the examination, even small increases in gamma-GTP levels should be considered a signal of early development of cholangiocarcinoma.