Circadian activity rhythm in methamphetamine-treated Clock mutant mice
Circadian activity rhythm in methamphetamine-treated Clock mutant mice
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DOI：
10.1046/j.0953-816x.2001.01749.x
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发表时间：
2001-10-01
影响因子：
3.4
通讯作者：
Honma, K
中科院分区：
文献类型：
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作者：
Masubuchi, S;Honma, S;Honma, K
众所周知，时钟基因对于表达哺乳动物在持续黑暗下的昼夜活动节律是必不可少的。时钟基因产物是分子反馈环路的积极组成部分，该环路被认为产生昼夜节律。另一方面，甲基苯丙胺(MAP)的慢性治疗在昼夜节律区域诱导运动活动节律，该节律独立于视交叉上核(SCN)，并由SCN外的起搏器驱动。然而，目前尚不清楚SCN外的起搏器是否具有与SCN内相似的分子机制。在这里，我们展示了在恒定的黑暗中，MAP恢复了心律失常纯合子时钟突变(时钟/时钟)小鼠的运动活动节律。这一结果表明，时钟突变不影响MAP诱发的运动节律。
It is well established that the Clock gene is essential for expressing circadian activity rhythms in mammals under constant darkness. The Clock gene product is a positive component of a molecular feedback loop which is assumed to generate the circadian rhythm. On the other hand, chronic treatment of methamphetamine (MAP) induces locomotor activity rhythm in a circadian domain, which is independent of the suprachiasmatic nucleus (SCN) and is driven by a pacemaker outside the SCN. However, it is not known whether the pacemaker outside the SCN possesses a similar molecular mechanism to that in the SCN. Here we show that MAP restores locomotor activity rhythm in arrhythmic homozygous Clock mutant (Clock/Clock) mice under constant darkness. This result indicates that the Clock mutation does not affect the MAP-induced locomotor rhythm.