Social evolution of shared biofilm matrix components.
Social evolution of shared biofilm matrix components.
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DOI：
10.1073/pnas.2123469119
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发表时间：
2022-07-05
影响因子：
11.1
通讯作者：
Yan, Jing
中科院分区：
文献类型：
--
作者：
Tai, Jung-Shen B.;Mukherjee, Saikat;Nero, Thomas;Olson, Rich;Tithof, Jeffrey;Nadell, Carey D.;Yan, Jing
生物膜是细菌生长的一种重要方式，表面附着的细胞享受由分泌的、可扩散的生物聚合物组成的细胞外基质提供的生存优势。一个重要的问题是，可扩散基质生产如何在开采的进化压力下保持稳定。在这里，我们表明霍乱弧菌生物膜中的一些基质蛋白确实可以被非生产者利用，但这种利用发生在生产者细胞团周围的一个可量化的空间范围内。一个考虑开采长度、规模和细胞群结构的生态模型揭示了扩散基质产生的稳定条件，与自然环境中的条件一致。我们的研究为研究空间结构细菌生物膜中的公共产品共享提供了概念和工具。生物膜的形成是细菌中一种重要且普遍存在的生长方式。生物膜形成的进化优势的核心是由各种因素实现的细胞与细胞和细胞表面的粘连，其中一些是可扩散的化合物，可以作为经典的公共产品--这些因素生产成本很高，但可能使其他细胞受益。一个悬而未决的问题是，通常情况下，可扩散的基质生产如何在进化时间尺度上保持稳定。在这项工作中，以霍乱弧菌为模型，我们证明了共享的可扩散的生物膜基质蛋白确实容易受到欺骗者的利用，并且产生这些基质组分的进化稳定性从根本上取决于生物膜的空间结构、这些组分的内在共享机制以及环境中的流动条件。我们进一步表明，可扩散黏附蛋白的开发局限于产生它们的细胞团周围一个明确定义的空间范围内。基于这一开发范围和细胞团的空间分布，我们构建了一个代价高昂的扩散基质生产模型，并将这些长度尺度与社会进化理论中的关联系数联系起来。我们的结果表明，在与自然生物膜生境和宿主环境一致的条件下，可扩散生物膜基质成分的产生在进化上是稳定的。我们希望这项研究揭示的机制与细菌群落中作为合作公共产品的其他分泌因子相关，开发范围的概念和相关分析工具将普遍适用。
Biofilms are an important mode of bacterial growth where surface-attached cells enjoy survival advantages provided by the extracellular matrix composed of secreted, diffusible biopolymers. An important question is how diffusible matrix production can be stable under the evolutionary pressure of exploitation. Here, we show that some matrix proteins in Vibrio cholerae biofilms can indeed be exploited by nonproducers, but the exploitation happens within a quantifiable spatial range around the producer cell clusters. An ecological model considering the length scales of exploitation and cell group structure reveals the stable conditions for diffusible matrix production that are consistent with those in natural environments. Our study provides concepts and tools for studying public goods sharing in spatially structured bacterial biofilms. Biofilm formation is an important and ubiquitous mode of growth among bacteria. Central to the evolutionary advantage of biofilm formation is cell–cell and cell–surface adhesion achieved by a variety of factors, some of which are diffusible compounds that may operate as classical public goods—factors that are costly to produce but may benefit other cells. An outstanding question is how diffusible matrix production, in general, can be stable over evolutionary timescales. In this work, using Vibrio cholerae as a model, we show that shared diffusible biofilm matrix proteins are indeed susceptible to cheater exploitation and that the evolutionary stability of producing these matrix components fundamentally depends on biofilm spatial structure, intrinsic sharing mechanisms of these components, and flow conditions in the environment. We further show that exploitation of diffusible adhesion proteins is localized within a well-defined spatial range around cell clusters that produce them. Based on this exploitation range and the spatial distribution of cell clusters, we constructed a model of costly diffusible matrix production and related these length scales to the relatedness coefficient in social evolution theory. Our results show that production of diffusible biofilm matrix components is evolutionarily stable under conditions consistent with natural biofilm habitats and host environments. We expect the mechanisms revealed in this study to be relevant to other secreted factors that operate as cooperative public goods in bacterial communities and the concept of exploitation range and the associated analysis tools to be generally applicable.
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DOI：
10.1126/science.1222981
发表时间：
2012-07-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Berk V;Fong JC;Dempsey GT;Develioglu ON;Zhuang X;Liphardt J;Yildiz FH;Chu S
通讯作者：
Chu S
影响因子：
18.3
作者：
Alcolombri, Uria;Peaudecerf, Francois J.;Stocker, Roman
通讯作者：
Stocker, Roman
DOI：
10.1016/s0967-0637(96)00104-5
发表时间：
1997-03-01
影响因子：
2.4
作者：
Diercks, AR;Asper, VL
通讯作者：
Asper, VL
影响因子：
4.1
作者：
Fischer, PF
通讯作者：
Fischer, PF
影响因子：
7.7
作者：
Fong, Jiunn C. N.;Rogers, Andrew;Yildiz, Fitnat H.
通讯作者：
Yildiz, Fitnat H.