Prognostic significance of Ki-67 and p53 as tumor markers in salivary gland malignancies in Finland:: An evaluation of 212 cases
Prognostic significance of Ki-67 and p53 as tumor markers in salivary gland malignancies in Finland:: An evaluation of 212 cases
复制标题
DOI：
10.1080/02841860500543208
复制
发表时间：
2006-09-01
期刊：
影响因子：
3.1
通讯作者：
Grenman, Reidar
中科院分区：
文献类型：
--
作者：
Luukkaa, Heikki;Klemi, Pekka;Grenman, Reidar
通过Ki-67核抗原测量的肿瘤的增殖能力是肿瘤行为的最有力指标之一。Ki-67被认为是确定恶性肿瘤侵袭性的有用工具。p53肿瘤抑制基因突变与许多不同类型癌症的发生和发展有关。应用免疫组化方法检测212例涎腺肿瘤石蜡包埋切片中p53抑癌蛋白和Ki-67体积校正指数（对应于肿瘤组织Ki-67/mm（2））。这项全国性的全人群研究的随访时间长达五年。临床病理特征和本研究的结果与生存的关联进行了检查。在多变量分析中，高VCI Ki-67与SGC患者的生存率较差相关（p = 0.0114）。根据年龄（p = 0.0002）、淋巴结状态（p = 0.0014）、性别（p = 0.0017）和分期（p = 0.0191）提供补充信息。与临床常用参数相比，p53表达在预测生存率方面没有额外的价值（p = 0.1433）。在这种材料组成的各种唾液腺癌VCI Ki-67是一个很好的预后因素的生存。
The proliferative capacity of a tumor as measured by Ki-67 nuclear antigen is one of the most powerful indicators of tumor behavior. Ki-67 is considered a useful tool in determining the aggressiveness of malignant neoplasms. p53 tumor suppressor gene mutations have been linked with the development and progression of a number of various cancer types. p53 tumor suppressor protein and the volume corrected index of Ki-67 corresponding to Ki-67/mm(2) of tumor tissue (VCI Ki-67) in salivary gland tumors were evaluated by immunohistochemistry from paraffin embedded sections in a series of 212 patients. The follow-up time in this nationwide full population-based study was up to five years. The association of clinicopathological features and the results of present study with survival were examined. In multivariate analysis high VCI Ki-67 was associated with worse survival of SGC patients (p = 0.0114). Supplementary information was brought by age (p = 0.0002), lymph node status (p = 0.0014), gender (p = 0.0017) and stage (p = 0.0191). p53 expression did not have additional value in prediction of survival (p = 0.1433) compared to the commonly clinical used parameters. In this material consisting of various salivary gland carcinomas VCI Ki-67 was a good prognostic factor for survival.