Shaping action sequences in basal ganglia circuits.
Shaping action sequences in basal ganglia circuits.
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DOI：
10.1016/j.conb.2015.06.011
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发表时间：
2015-08
影响因子：
5.7
通讯作者：
Costa RM
中科院分区：
文献类型：
--
作者：
Jin X;Costa RM
生物体生存所必需的许多行为都是重新学习的，并被组织成一系列复杂的行动。最近的研究表明，皮质-基底神经节回路对于将孤立的运动分割成精确而有力的动作序列，从而实现特定的目标非常重要。在序列学习过程中，基底神经节中的许多神经元产生与序列相关的活动——与序列的启动、执行和终止有关——表明动作序列被作为动作单元处理。皮质纹状体的可塑性对于动作序列的结晶和与序列相关的神经活动的发展至关重要。此外，这种序列相关的活性在直接和间接基底神经节通路中表达不同。这些发现对理解与运动和精神障碍相关的症状具有启示意义。
Many behaviors necessary for organism survival are learned anew and become organized as complex sequences of actions. Recent studies suggest that cortico-basal ganglia circuits are important for chunking isolated movements into precise and robust action sequences that permit the achievement of particular goals. During sequence learning many neurons in the basal ganglia develop sequence-related activity - related to the initiation, execution, and termination of sequences - suggesting that action sequences are processed as action units. Corticostriatal plasticity is critical for the crystallization of action sequences, and for the development of sequence-related neural activity. Furthermore, this sequence-related activity is differentially expressed in direct and indirect basal ganglia pathways. These findings have implications for understanding the symptoms associated with movement and psychiatric disorders.