Physical activity and food consumption in high- and low-active inbred mouse strains.
Physical activity and food consumption in high- and low-active inbred mouse strains.
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DOI：
10.1249/mss.0b013e3181daf5e8
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发表时间：
2010-10
影响因子：
4.1
通讯作者：
Lightfoot JT
中科院分区：
文献类型：
--
作者：
Jung AP;Curtis TS;Turner MJ;Lightfoot JT
研究先天活动水平和转轮活动对高活动（SWR/J）低活动（DBA/2 J）小鼠摄食量的影响。本研究使用了两个品系的近交系小鼠，由于它们的高活动水平（SWR/J）和低活动水平（DBA/2 J）。小鼠被关在单独的笼子里，每个品系中有一半的小鼠可以自由使用笼子里的转轮，而其他小鼠则没有转轮。在研究期间，所有小鼠自由进食标准食物和水13周。记录跑轮活动（每日）、摄食量（每两周一次）和体重（每周一次）。SWR/J跑步者（6.0±0.4g/天）比SWR/J非跑步者（4.7±0.2g/天; p=0.03）、DBA/2 J跑步者（4.6±0.2g/天; p=0.02）和DBA/2 J非跑步者（4.2±0.2g/天; p=0.006）消耗更多的食物。SWR/J非跑步者比DBA/2 J非跑步者消耗更多的食物（p=0.03）。SWR/J组的平均每日距离和持续时间（分别为6.4± 0.7 km/d和333.6± 40.5 min/d）显著高于DBA/2 J组（分别为1.6± 0.4 km/d和91.3± 23.0 min/d）。在所有小鼠中，食物消耗与距离（r=0.74，p<0.001）、持续时间（r=0.68，p<0.001）和速度（r=0.58，p<0.001）之间分别存在显著相关性。然而，当考虑到个体品系时，转轮活动和食物消耗之间的关系仅在SWR/J小鼠中具有统计学显著性。小鼠中较高的转轮活动与SWR/J小鼠的食物消耗增加相关，但与DBA/2 J小鼠无关。在DBA/2 J小鼠中，添加跑步轮不会导致食物消耗增加，这表明对照DBA/2 J小鼠中的非轮笼活动的能量消耗与轮活动的能量消耗相似，因为两组之间的体重相似。
To determine the effect of innate activity level and running wheel access on food consumption in high-active (SWR/J) low-active (DBA/2J) mice. Two strains of inbred mice were used in this study due to their high activity level (SWR/J) and low activity level (DBA/2J). The mice were housed in individual cages, and half of the mice in each strain had free access to running wheels in their cages, while the other mice received no running wheel. All mice consumed standard chow and water ad libitum for 13 weeks during the study period. Running-wheel activity (daily), food consumption (bi-weekly), and body mass (weekly) were recorded. SWR/J runners consumed more food (6.0±0.4g/day) than SWR/J non-runners (4.7±0.2g/day; p=0.03), DBA/2J runners (4.6±0.2g/day; p=0.02), and DBA/2J non-runners (4.2±0.2g/day; p=0.006). SWR/J non-runners consumed more food than DBA/2J non-runners (p=0.03). Average daily distance and duration were significantly greater for the SWR/J runners (6.4±0.7km/day and 333.6±40.5min/day, respectively) compared to the DBA/2J runners (1.6±0.4km/day and 91.3±23.0min/day, respectively). There was a significant correlation between food consumption and distance (r=0.74, p<0.001), duration (r=0.68, p<0.001), and speed (r=0.58, p<0.001), respectively, in all mice. However, when considering the individuals strains, the relationship between running-wheel activity and food consumption was only statistically significant for the SWR/J mice. Higher running-wheel activity in mice was associated with increased food consumption in the SWR/J mice but not the DBA/2J mice. In DBA/2J mice the addition of a running wheel did not result in increased food consumption, suggesting energy expenditure of non-wheel cage activity in the control DBA/2J mice was similar to the energy expenditure of the wheel activity since body mass was similar between the two groups.