INVIVO STUDIES OF THE EVOLUTION OF PHYSICAL-PROPERTIES OF THE HUMAN-SKIN WITH AGE
INVIVO STUDIES OF THE EVOLUTION OF PHYSICAL-PROPERTIES OF THE HUMAN-SKIN WITH AGE
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DOI：
10.1111/j.1365-4362.1984.tb04061.x
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
AGACHE, P
中科院分区：
文献类型：
--
作者：
LEVEQUE, JL;CORCUFF, P;AGACHE, P
通过有效的方法进行体内测量，有助于解释与衰老过程相关的现象。作者开发了一些常规技术来测量真皮-表皮深处和皮肤的物理特性。表面（角质层）。对150人的前臂进行的测量得出了以下关于真皮-表皮水平的结果：(1)男性和女性的皮肤厚度在45岁时开始下降，此时女性的皮肤比男性的皮肤薄；(2)在给定皮厚的情况下，扭转伸长率在20岁后急剧下降；(3)皮肤光学特性被修改，即在额头上测量到的光容积脉搏波信号，60岁后大大增加；(4)在皮肤表面水平上，主要的变化是60岁后角质层脱落增加，同时角质层内聚性改变，衰老过程中皮肤微松度改变，经皮水分流失略有减少，而角质层投射大小增加。这些发现允许考虑老化过程在皮肤水平作为一个阶段性的过程。物理性质及其动力学的变化表明，根据不同的皮肤切片有不同的过程。
In vivo measurements taken by valid methods, help to interpret the phenomena associated with the aging process. The authors developed some routine techniques to measure physical properties of the skin both deep in the dermis-epidermis and at the. surface (stratum corneum). Measurements on the forearm of 150 people yielded the following results regarding the dermis-epidermis level:(1) skin thickness begins to decrease at 45 years of age for men and women, when women's skin becomes thinner than men's skin;(2) torsion extensibility, normalized for a given skin thickness, sharply decreases after US years of age;(3) skin optical properties are modified, ie the photoplethysmographic signal, measured on the forehead, greatly increase after 60 years of age;(4) at the cutaneous surface level, the main modifications are increased shedding of stratum corneum after 60 years of age in parallel with a modification of the stratum corneum cohesivity, altered skin microrelief during the aging process, and slightly decreased transepidermal water loss while the corneocyte projected size increases. These findings allow consideration of the aging process at the skin level as a phased process. The alterations of the physical properties and their kinetics suggest a various process according to the different cutaneous sections.