The variability of human, BOLD hemodynamic responses
The variability of human, BOLD hemodynamic responses
复制标题
DOI：
10.1006/nimg.1998.0369
复制
发表时间：
1998-11-01
期刊：
影响因子：
5.7
通讯作者：
D'Esposito, M
中科院分区：
文献类型：
--
作者：
Aguirre, GK;Zarahn, E;D'Esposito, M
脑血流动力学对短暂的神经活动的反应是延迟的，并且在时间上是分散的。这些反应的特定形状对于血氧水平依赖性（BOLD）、功能性磁共振成像（fMRI）实验的设计和分析具有一定的重要性。使用功能磁共振成像扫描，我们在这里研究的特点和变异性的血液动力学反应，从中央沟在人类受试者在一个事件相关的，简单的反应时间任务。具体来说，我们确定的主题，天，扫描会话（一天内）的诱发血流动力学反应的形状的变异性的贡献。我们发现，虽然有显着的和实质性的变化，在跨学科收集的响应的形状，在一个单一的主题多次扫描过程中收集的响应变量较小。结果进行了讨论的敏感性和特异性的事件相关的功能磁共振成像设计分析的反应变异性的影响。(C)北京：科学出版社.
Cerebral hemodynamic responses to brief periods of neural activity are delayed and dispersed in time. The specific shape of these responses is of some importance to the design and analysis of blood oxygenation level-dependent (BOLD), functional magnetic resonance imaging (fMRI) experiments. Using fMRI scanning, we examine here the characteristics and variability of hemodynamic responses from the central sulcus in human subjects during an event-related, simple reaction time task. Specifically, we determine the contribution of subject, day, and scanning session (within a day) to variability in the shape of evoked hemodynamic response. We find that while there is significant and substantial variability in the shape of responses collected across subjects, responses collected during multiple scans within a single subject are less variable. The results are discussed in terms of the impact of response variability upon sensitivity and specificity of analyses of event-related fMRI designs. (C) 1998 Academic Press.