Emotion-induced changes in human medial prefrontal cortex: I. During cognitive task performance
Emotion-induced changes in human medial prefrontal cortex: I. During cognitive task performance
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DOI：
10.1073/pnas.98.2.683
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发表时间：
2001-01-16
影响因子：
11.1
通讯作者：
Raichle, ME
中科院分区：
文献类型：
--
作者：
Simpson, JR;Snyder, AZ;Raichle, ME
在被试执行两项认知任务（大声朗读名词以及为相同名词生成合适的动词）时，利用正电子发射断层扫描技术对内侧前额叶皮质（MPFC）区域的局部脑血流（BF）进行了检测。控制任务是被动观看相同的单词。与被试被动观看名词的控制状态相比，在单词朗读和初次动词生成过程中，MPFC区域的脑血流减少。通过反应时间来衡量，动词生成练习提高了表现，这与MPFC和下丘脑脑血流的进一步减少密切相关。经过练习，当对一组新的单词进行动词生成时，反应时间变慢，MPFC脑血流模式恢复到单词朗读和初次条件下的情况。对动词生成任务的另一项单独行为研究表明，通过心率和自我报告测量，在初次动词生成过程中焦虑程度较高，随着任务练习焦虑程度降低，但随着一组新单词的引入又会回升。综上所述，这些结果表明，MPFC是一个网络的一部分，该网络包括下丘脑和脑干，其活动反映了认知任务表现和情绪之间的动态相互作用。
Regional cerebral blood flow (BF) was examined in regions of the medial prefrontal cortex (MPFC) with positron-emission tomography while subjects performed two cognitive tasks, reading nouns aloud and generating appropriate Verbs for the same nouns. The control task was passive viewing of the same words. BF was reduced in regions of the MPFC during word reading and naive verb generation, relative to a control state in which the subjects passively viewed nouns. Practicing verb generation produced improved performance, as measured by response time, which was strongly correlated with further reductions in MPFC and hypothalamic BF, After practice, when verb generation was performed on a novel list of words, reaction times slowed and the pattern of MPFC BF reverted to that seen in the word reading and naive conditions. A separate behavioral study of the verb-generation task indicated that anxiety, high during naive use-generation as measured by heart rate and self-report, decreased with practice on the task but returned with the introduction of a novel list of words. Taken together, these results suggest that the MPFC is part of a network, including the hypothalamus and brainstem, whose activity reflects a dynamic interplay between cognitive task performance and emotion.