Tales from topographic oceans: topologically associated domains and cancer.
Tales from topographic oceans: topologically associated domains and cancer.
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DOI：
10.1530/erc-19-0348
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发表时间：
2019-11
影响因子：
3.9
通讯作者：
Campbell MJ
中科院分区：
文献类型：
--
作者：
Campbell MJ
The three-dimensional organization of the genome within the cell nucleus has come into sharp focus over the last decade. This has largely arisen because of the application of genomic approaches that have revealed numerous levels of genomic and chromatin interactions, including topologically associated domains (TADs). The current review examines how these domains were identified, are organized, how their boundaries arise and are regulated, and how genes within TADs are coordinately regulated. There are many examples of the disruption to TAD structure in cancer and the altered regulation, structure and function of TADs are discussed in the context of hormone responsive cancers, including breast, prostate and ovarian cancer. Finally, some aspects of the statistical insight and computational skills required to interrogate TAD organization are considered and future directions discussed.
影响因子：
3.7
作者：
Tsui, Shanli;Gao, Jie;Wang, Charles;Lu, Luo
通讯作者：
Lu, Luo
影响因子：
14.9
作者：
Tsai YC;Cooke NE;Liebhaber SA
通讯作者：
Liebhaber SA