Anti-phytopathogenic Bacterial Metabolites From the Seaweed-Derived Fungus Aspergillus sp. D40
Anti-phytopathogenic Bacterial Metabolites From the Seaweed-Derived Fungus Aspergillus sp. D40
复制标题
来自海藻衍生真菌曲霉属的抗植物病原细菌代谢物。
DOI：
10.3389/fmars.2020.00313
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发表时间：
2020-05-15
影响因子：
3.7
通讯作者：
Zhang, Cheng-Sheng
中科院分区：
文献类型：
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作者：
Huang, Rui-Huan;Lin, Wei;Zhang, Cheng-Sheng
为了寻找新的具有抗植物病原菌活性的先导化合物，从海藻源真菌Aspergillus sp. D40中分离得到3对新的呋喃酮衍生物sclerocellumins D-F（1-3）和8个已知化合物（4-11）。利用HRESIMS、1D和2D NMR等波谱分析手段对它们的结构进行了表征。化合物1-4和9作为一对差向异构体的不可分离的混合物存在。青霉酸（7）对青枯菌和其他几种植物病原菌具有明显的抗菌活性，IC_（50）为11.6 ~ 58.2 μ g/mL。
In order to search for new lead compounds with anti-phytopathogenic bacterial activity, three pairs of new furanone derivatives, sclerotiorumins D-F (1-3), and eight known compounds (4-11) were isolated from the seaweed-derived fungus, Aspergillus sp. D40, fermented with potato dextrose seawater (PDW) medium. Their structures were determined using comprehensive spectroscopic analyzes including HRESIMS, 1D and 2D NMR data. Compounds 1-4 and 9 existed as inseparable mixtures of a pair of epimers. Penicillic acid (7) exhibited clear antibacterial activity against Ralstonia solanacearum and several other plant pathogenic bacteria with IC50 values ranging from 11.6 to 58.2 mu g/mL.