Dose-dependent effects of intravitreal kainic acid on specific cell types in chicken retina
Dose-dependent effects of intravitreal kainic acid on specific cell types in chicken retina
复制标题
玻璃体内红藻氨酸对鸡视网膜特定细胞类型的剂量依赖性影响
DOI：
10.1016/0306-4522(83)90054-4
复制
发表时间：
1983
期刊：
影响因子：
3.3
通讯作者：
I. Morgan
中科院分区：
文献类型：
--
作者：
C. A. Ingham;I. Morgan
在鸡的视网膜中，大约三分之二的双极细胞和大多数无长突细胞在玻璃体内注射20到60nmol海人藻酸后被破坏。这些细胞，加上水平细胞，在玻璃体内注射120毫摩尔的海人藻酸后被破坏。三分之一的双极细胞、Müler胶质细胞、光感受器和神经节细胞似乎更具抵抗力。神经节细胞对玻璃体内红藻氨酸的抵抗力是不寻常的，在哺乳动物的视网膜中没有发现。多巴胺能无长突细胞也可能对海人酸有抵抗力，提示海人酸直接与双极细胞和水平细胞相互作用，使双极细胞和水平细胞去极化，从而杀死它们，同时使双极细胞超极化。讨论了无长突细胞死亡可能是红藻氨酸对双极细胞作用的间接结果的可能性。无论红藻氨酸导致细胞死亡的确切方式是什么，造成损伤的技术对于确定视网膜，特别是无长突细胞递质系统的定位是有用的。
In chicken retina, approximately two thirds of the bipolar cells and most amacrine cells are destroyed after intravitreal injection of from 20 to 60 nmoles of kainic acid. These cells, plus horizontal cells are destroyed after intravitreal injections of 120 nmoles of kainic acid. One third of the bipolar cells, Müller glial cells, photoreceptors and ganglion cells seem to be much more resistant. The resistance of the ganglion cells to intravitreal kainic acid is unusual and is not found in mammalian retinas. Dopaminergic amacrine cells may also be resistant to kainic acid.It is suggested that kainic acid interacts directly with bipolar cells and horizontal cells, depolarising the bipolar cells and horizontal cells and thereby killing them, while hyperpolarizing the ON-bipolar cells. The possibility that amacrine cell death may be an indirect result of kainic acid's effects on bipolar cells is discussed. Whatever the precise way in which kainic acid causes cell death, the technique of causing lesions is useful for defining the localization of retinal and particularly amacrine cell transmitter systems.
GABA 和谷氨酸作为兔视网膜中的视网膜神经递质。
DOI：
--
发表时间：
1981
期刊：
Advances in biochemical psychopharmacology
影响因子：
--
作者：
Redburn,DA
通讯作者：
Redburn,DA