Hypothyroxinemia During Gestation and Offspring Schizophrenia in a National Birth Cohort
Hypothyroxinemia During Gestation and Offspring Schizophrenia in a National Birth Cohort
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DOI：
10.1016/j.biopsych.2015.06.014
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发表时间：
2016-06-15
影响因子：
10.6
通讯作者：
Brown, Alan S.
中科院分区：
文献类型：
--
作者：
Gyllenberg, David;Sourander, Andre;Brown, Alan S.
BACKGROUND: Evidence from animal and human studies indicates that thyroid hormone deficiency during early gestation alters brain development. As schizophrenia is associated with prenatal brain insults and premorbid cognitive deficits, we tested the a priori hypothesis that serologically defined maternal thyroid deficiency during early gestation to mid-gestation is associated with schizophrenia in offspring.METHODS: The investigation is based on the Finnish Prenatal Study of Schizophrenia, a nested case-control study that included archived maternal sera from virtually all pregnancies since 1983 (N = .1 million). We identified all offspring in the cohort with a diagnosis of schizophrenia based on the national inpatient and outpatient register and matched them on sex, date of birth, and residence in Finland at time of onset of the case to comparison subjects (1:1) from the cohort. Maternal sera of 1010 case-control pairs were assessed for free thyroxine, and sera of 948 case-control pairs were assessed for thyroid-stimulating hormone.RESULTS: Maternal hypothyroxinemia (free thyroxine
