ILEI: a novel marker for epithelial-mesenchymal transition and poor prognosis in colorectal cancer
ILEI: a novel marker for epithelial-mesenchymal transition and poor prognosis in colorectal cancer
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ILEI：结直肠癌上皮间质转化和不良预后的新标志物。
DOI：
10.1111/his.12435
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发表时间：
2014-10-01
期刊：
影响因子：
6.4
通讯作者：
Xu, Hui-Mian
中科院分区：
文献类型：
--
作者：
Gao, Zhao-Hua;Lu, Chong;Xu, Hui-Mian
目的：在过去的十年中，越来越多的证据表明，上皮细胞到间充质转化（EMT）的异常激活有助于结直肠癌（CRC）的肿瘤进展和转移。本研究通过研究白细胞介素样EMT诱导剂（ILEI）及EMT相关标志物（E-cadherin、vimentin）在结直肠癌组织中的表达，确定ILEI表达与结直肠癌临床病理特征、预后及EMT的相关性。方法和结果对2003 ~ 2005年在中国医科大学第一医院经组织病理学诊断为结直肠癌并行手术切除的194例患者进行回顾性分析。对每个标本进行ILEI、vimentin和E-cadherin的免疫组化染色。ILEI的细胞质过表达通常伴随着E-cadherin的下调和vimentin的阳性表达。相反，ILEI在E-cadherin过表达和vimentin负表达的同时下调。ILEI过表达与t期、n期、TNM期和EMT表型显著相关(P=0.024；
AimsAccumulating evidence over the past decade has shown that abnormal activation of epithelial to mesenchymal transition (EMT) contributes to tumour progression and metastasis in colorectal cancer (CRC). In this study, we investigated the expression of interleukin-like EMT inducer (ILEI) and EMT-associated markers (E-cadherin, vimentin) in CRC tissues and determined the correlations between ILEI expression and clinicopathological characteristics, prognosis and EMT in CRC.Methods and resultsIn total, 194 patients diagnosed with CRC based on histopathological evaluation and those subjected to surgical resection at the First Hospital of China Medical University between 2003 and 2005 were examined. Immunohistochemical staining for ILEI, vimentin and E-cadherin was performed for each specimen. Cytoplasmic overexpression of ILEI usually accompanied down-regulation of E-cadherin and positive expression of vimentin. Conversely, ILEI was simultaneously down-regulated with overexpression of E-cadherin and negative expression of vimentin. ILEI overexpression was associated significantly with T-stage, N-stage, TNM stage and EMT phenotype (P=0.024,