Brain lesion location and clinical status 20 years after a diagnosis of clinically isolated syndrome suggestive of multiple sclerosis
Brain lesion location and clinical status 20 years after a diagnosis of clinically isolated syndrome suggestive of multiple sclerosis
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DOI：
10.1177/1352458511420269
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发表时间：
2012-03-01
影响因子：
5.8
通讯作者：
Chard, D. T.
中科院分区：
文献类型：
--
作者：
Dalton, C. M.;Bodini, B.;Chard, D. T.
背景/目的：本研究的目的是调查一组患者在出现提示多发性硬化症（MS）的临床孤立综合征（CIS）后20年随访的脑病变空间分布与临床结局之间的相关性。从74名接受磁共振成像（MRI）的患者中生成T1和T2病变的脑病变概率图（LPM）临床评估为CIS术后平均19.9年。单尾t检验统计量用于比较以下组之间的LPM：临床确诊（CD）MS和MRI异常的CIS患者; MS和扩展残疾状态量表（EDSS）3的患者;复发缓解型（RR）和继发性进展型（SP）患者使用多元线性回归模型分析每个体素病变的概率，并根据年龄和性别进行调整。CDMS患者比CIS患者和发病后20年扫描异常的患者更有可能在放射冠、视放射和胼胝体压部（室周）出现T1和T2病变，在右侧额枕束出现T2病变。MS EDSS > 3的人与EDSS的人相比
Background/Objectives: The objective of this study was to investigate associations between the spatial distribution of brain lesions and clinical outcomes in a cohort of people followed up 20 years after presentation with a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS).Methods: Brain lesion probability maps (LPMs) of T1 and T2 lesions were generated from 74 people who underwent magnetic resonance imaging (MRI) and clinical assessment a mean of 19.9 years following a CIS. One-tailed t-test statistics were used to compare LPMs between the following groups: clinically definite (CD) MS and those who remained with CIS, with an abnormal MRI; people with MS and an Expanded Disability Status Scale (EDSS) 3; people with relapsing-remitting (RR) and secondary progressive (SP) MS. The probability of each voxel being lesional was analysed adjusting for age and gender using a multiple linear regression model.Results: People with CDMS were significantly more likely than those with CIS and abnormal scan 20 years after onset to have T1 and T2 lesions in the corona radiata, optic radiation, and splenium of the corpus callosum (periventricularly) and T2 lesions in the right fronto-occipital fasciculus. People with MS EDSS > 3, compared with those with EDSS