LIFR-BETA AND GP-130 AS HETERODIMERIZING SIGNAL TRANSDUCERS OF THE TRIPARTITE CNTF RECEPTOR
LIFR-BETA AND GP-130 AS HETERODIMERIZING SIGNAL TRANSDUCERS OF THE TRIPARTITE CNTF RECEPTOR
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DOI：
10.1126/science.8390097
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发表时间：
1993-06-18
期刊：
影响因子：
56.9
通讯作者：
YANCOPOULOS, GD
中科院分区：
文献类型：
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作者：
DAVIS, S;ALDRICH, TH;YANCOPOULOS, GD
这里显示的睫状神经营养因子 (CNTF) 受体复合物包括 CNTF 结合蛋白 (CNTFRalpha) 以及白血病抑制因子 (LIF) 受体的成分、LIFRbeta（LIF 结合蛋白）和 gp130 [白细胞介素 6 (IL-6) 的信号转导器]。因此，二联LIF受体向三联CNTF受体的转化显然是通过添加赋予特异性的元件CNTFRα而发生的。 CNTF 和 LIF 都会触发最初独立的受体成分的结合，进而导致受体亚基的酪氨酸磷酸化。与 IL-6 受体复合物（其中 gp130 的同二聚化似乎对于信号起始至关重要）不同，CNTF 和 LIF 受体复合物的信号传导取决于 gp130 与 LIFRbeta 的异二聚化。配体诱导的信号转导受体成分的二聚化（也见于受体酪氨酸激酶）可能提供信号跨细胞膜传输的一般机制。
The ciliary neurotrophic factor (CNTF) receptor complex is shown here to include the CNTF binding protein (CNTFRalpha) as well as the components of the leukemia inhibitory factor (LIF) receptor, LIFRbeta (the LIF binding protein) and gp130 [the signal transducer of interleukin-6 (IL-6)]. Thus, the conversion of a bipartite LIF receptor into a tripartite CNTF receptor apparently occurs by the addition of the specificity-conferring element CNTFRalpha. Both CNTF and LIF trigger the association of initially separate receptor components, which in turn results in tyrosine phosphorylation of receptor subunits. Unlike the IL-6 receptor complex in which homodimerization of gp130 appears to be critical for signal initiation, signaling by the CNTF and LIF receptor complexes depends on the heterodimerization of gp130 with LIFRbeta. Ligand-induced dimerization of signal-transducing receptor components, also seen with receptor tyrosine kinases, may provide a general mechanism for the transmission of a signal across the cell membrane.