Dopaminergic correlates of metabolic network activity in Parkinson's disease
Dopaminergic correlates of metabolic network activity in Parkinson's disease
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DOI：
10.1002/hbm.22863
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发表时间：
2015-09-01
影响因子：
4.8
通讯作者：
Eggers, Carsten
中科院分区：
文献类型：
--
作者：
Holtbernd, Florian;Ma, Yilong;Eggers, Carsten
帕金森病 (PD) 与独特的代谢协方差模式相关，这些模式与该疾病的运动和认知表现相关。然而，尚不清楚这些模式的表达如何与同一个体的黑质纹状体多巴胺能活性的测量相关。为了探索这些关联，我们研究了 106 名 PD 受试者，他们接受了 F-18-氟脱氧葡萄糖 (FDG) 和 F-18-氟-L-多巴 (FDOPA) 脑部 PET 检查。计算每个受试者的 PD 运动和认知相关代谢模式（分别为 PDRP 和 PDCP）的表达值；这些测量值与逐个体素的 FDOPA 摄取相关。为了探索多巴胺能功能和局部代谢活动之间的关系，将尾状核和壳核 FDOPA PET 信号与整个大脑的 FDG 摄取进行体素相关。 PDRP 表达与尾状核和壳核中 FDOPA 摄取相关（P
Parkinson's disease (PD) is associated with distinct metabolic covariance patterns that relate to the motor and cognitive manifestations of the disorder. It is not known, however, how the expression of these patterns relates to measurements of nigrostriatal dopaminergic activity from the same individuals. To explore these associations, we studied 106 PD subjects who underwent cerebral PET with both F-18-fluorodeoxyglucose (FDG) and F-18-fluoro-L-dopa (FDOPA). Expression values for the PD motor- and cognition-related metabolic patterns (PDRP and PDCP, respectively) were computed for each subject; these measures were correlated with FDOPA uptake on a voxel-by-voxel basis. To explore the relationship between dopaminergic function and local metabolic activity, caudate and putamen FDOPA PET signal was correlated voxel-wise with FDG uptake over the entire brain. PDRP expression correlated with FDOPA uptake in caudate and putamen (P