Associations between duration of untreated psychosis and domains of positive and negative symptoms.
Associations between duration of untreated psychosis and domains of positive and negative symptoms.
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DOI：
10.1111/eip.12256
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发表时间：
2017-10
影响因子：
2
通讯作者：
Compton MT
中科院分区：
文献类型：
--
作者：
Birnbaum ML;Wan CR;Broussard B;Compton MT
未经治疗的精神病（DUP）的持续时间已被确定为首次发作精神病样本中阴性结果的独立和重要预测因素。尽管文献支持DUP与阳性和阴性症状严重程度之间的关联，但迄今为止，令人惊讶的是，很少有研究专门探讨了哪些类型的阳性和阴性症状与DUP最相关。在2008年8月至2013年6月期间，收集了247名首发精神病参与者（平均年龄：23.9 ± 4.8）的DUP，阳性症状评估量表（SAPS）和阴性症状评估量表（SANS）数据。DUP与幻觉（ρ = 0.222; P = 0.001）、妄想（r = 0.202; P = 0.003）和正式思维障碍（ρ = 0.138; P = 0.043）的严重程度显著但适度相关，但与怪异行为无关。DUP与SANS的回避-冷漠（ρ = 0.164; P = 0.016）和快感缺乏-不合群（r = 0.321; P < 0.001）子量表显著但适度相关，但与情感扁平化或迟钝、失语或注意力无关。DUP是一种复杂而多方面的现象，与早期疾病发展有关。在努力改善早期干预服务，治疗和结果的过程中，了解导致长期未治疗精神病的因素以及受未治疗精神病影响的疾病特征至关重要。
The duration of untreated psychosis (DUP) has been established as an independent and significant predictor of negative outcomes in first-episode psychosis samples. Whereas literature has supported the association between DUP and severity of positive and negative symptoms, surprisingly little research to date has explored specifically what types of positive and negative symptoms are most associated with DUP. DUP, Scale for the Assessment of Positive Symptoms (SAPS) and Scale for the Assessment of Negative Symptoms (SANS) data were collected in 247 first-episode psychosis participants (mean age: 23.9 ± 4.8) between August 2008 and June 2013. DUP was significantly but modestly associated with the severity of hallucinations (ρ = 0.222; P = 0.001), delusions (r = 0.202; P = 0.003) and formal thought disorder (ρ = 0.138; P = 0.043) but was not associated with bizarre behaviour. DUP was significantly but modestly associated with SANS avolition-apathy (ρ = 0.164; P = 0.016) and anhedonia-asociality (r = 0.321; P < 0.001) subscales but was not associated with affective flattening or blunting, alogia or attention. DUP is a complex and multifaceted phenomenon that is associated with early-course illness development. In efforts to improve early intervention services, prognoses and outcomes, it is vital to understand both the factors that contribute to lengthy untreated psychosis as well as the illness characteristics that are impacted by untreated psychosis.