Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy
Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy
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DOI：
10.1016/s0006-8993(01)02743-3
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发表时间：
2001-09-14
期刊：
影响因子：
2.9
通讯作者：
Toyka, KV
中科院分区：
文献类型：
--
作者：
Sommer, C;Lindenlaub, T;Toyka, KV
我们研究了肿瘤坏死因子-α（TNF）的中和抗体（AB）在两种小鼠神经病变模型中的抗痛觉过敏作用，即具有强烈神经外膜炎性成分的慢性坐骨神经损伤（CCI）和部分坐骨神经横断（PST），一种“纯”神经损伤模型。在这两种模型中，术中以及第4天单次注射AB显著降低了热痛觉过敏，而机械性异常性疼痛仅在术中降低，而延迟治疗则没有降低。(C)2001 Elsevier Science B. V.保留所有权利。
We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-alpha (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment. (C) 2001 Elsevier Science B.V. All rights reserved.