RISK-FACTORS FOR CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE - A CASE-CONTROL STUDY OF AN ITALIAN POPULATION
RISK-FACTORS FOR CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE - A CASE-CONTROL STUDY OF AN ITALIAN POPULATION
复制标题
DOI：
10.1212/wnl.36.7.922
复制
发表时间：
1986-07-01
期刊：
影响因子：
9.9
通讯作者：
SCHOENBERG, BS
中科院分区：
文献类型：
--
作者：
AMADUCCI, LA;FRATIGLIONI, L;SCHOENBERG, BS
我们对意大利7个中心的116例临床诊断为阿尔茨海默病（AD）的患者进行了病例对照研究。116例医院对照和97例人群对照按年龄、性别和居住地区与病例相匹配。一个结构化的问卷调查管理的近亲的情况下，控制由训练有素的面试官，以确定可能的危险因素。遗传，病毒，毒性，免疫，医疗，手术和个性因素进行了调查。一级或二级亲属中的痴呆症和受试者出生时母亲的高龄（40岁以上）与AD相关。头部创伤的情况下，更频繁的医院或人口控制，但差异不显着。我们的数据并没有证实先前报道的与甲状腺疾病或唐氏综合征家族史的关系。
We conducted a case-control study of 116 patients with the clinical diagnosis of Alzheimer''s disease (AD) in seven Italian centers. One hundred sixteen hospital control and 97 population controls were matched by age, sex, and region of residence to the cases. A structured questionnaire was administered to the next-of-kin of cases and controls by trained interviewers to identify possible risk factors. Genetic, viral, toxic, immunologic, medical, surgical, and personality factors were investigated. Dementia among first- or second-degree relatives and advanced age of the mother at subject''s birth (age over 40) were associated with AD. Head trauma was more frequent in cases than in either hospital or population controls, but the differences were not significant. Our data did not confirm the previously reported association with antecedent thyroid disease or family history of Down''s syndrome.