Learning in a geometric model of place cell firing
Learning in a geometric model of place cell firing
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DOI：
10.1002/hipo.20324
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Burgess, Neil
中科院分区：
文献类型：
--
作者：
Barry, Caswell;Burgess, Neil
遵循Hartley等人的观点。(Hartley等人)(2000)海马体10：369-379)，我们提出了一个简单的前馈模型的位置细胞(PC)放电预测的新皮质信息有关的环境几何动物。结合具有不同感觉特性的边界的概念，我们证明了突触可塑性由BCM类规则介导(Bienenstock等人。(1982)J Neurosci 2：3248)生产的PC编码相对于特定扩展地标的位置。在不变的环境中，模型经历了学习的初始阶段，导致了稳定的位置场的形成。在熟悉的环境中，环境线索的扰动会导致位置场的射速和位置发生渐变。模型模拟与三组实验数据进行了比较：(1)Barry等人发表的结果。(Barry等人)(2006)Neurosci牧师17：7197)展示了当障碍被放置到熟悉的环境中时所产生的重复位置场的缓慢消失。(2)Rivard等人(Rivard等人(2004年)J Gen Physiol124：9-25)的研究显示了PC激发中的分级响应，使得靠近中心放置的对象的场相对于对象编码空间，而较远的场对周围环境做出响应。(3)Fenton等人(Fenton等人(Fenton et al.(2000a)J Gen Physiol116：191-209)观察到提示卡的不一致旋转导致场位位置的参数变化。(C)2007年Wiley-Liss，Inc.讨论了该模型的优点。
Following Hartley et al. (Hartley et al. (2000) Hippocampus 10:369-379), we present a simple feed-forward model of place cell (PC) firing predicated on neocortical information regarding the environmental geometry surrounding the animal. Incorporating the idea of boundaries with distinct sensory qualities, we show that synaptic plasticity mediated by a BCM-like rule (Bienenstock et al. (1982) J Neurosci 2:3248) produces PCs that encode position relative to specific extended landmarks. In an unchanging environment the model is shown to undergo an initial phase of learning, resulting in the formation of stable place fields. In familiar environments, perturbation of environmental cues produces graded changes in the firing rate and position of place fields. Model simulations are compared favorably with three sets of experimental data: (1) Results published by Barry et al. (Barry et al. (2006) Rev Neurosci 17:7197) showing the slow disappearance of duplicate place fields produced when a barrier is placed into a familiar environment. (2) Rivard et al.'s (Rivard et al. (2004) J Gen Physiol 124:9-25) study showing a graded response in PC firing such that fields near to a centrally placed object encode space relative to the object, whereas more distant fields respond to the surrounding environment. (3) Fenton et al.'s (Fenton et al. (2000a) J Gen Physiol 116:191-209) observation that inconsistent rotation of cue cards produces parametric changes in place field positions. The merits of the model are discussed in terms of its extensibility and biological plausibility. (C) 2007 Wiley-Liss, Inc.