Origins of DNA replication
Origins of DNA replication
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DOI：
10.1371/journal.pgen.1008320
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发表时间：
2019-09-01
期刊：
影响因子：
4.5
通讯作者：
Bleichert, Franziska
中科院分区：
文献类型：
--
作者：
Ekundayo, Babatunde;Bleichert, Franziska
在所有的生命王国中，用来编码遗传信息。遗传物质在世代之间的繁殖需要在细胞分裂之前及时准确地复制DNA，以确保每个子细胞都能获得完整的DNA。子链的DNA合成在称为复制起点的离散位点开始，并且以双向方式进行，直到所有基因组DNA被复制。尽管这些事件的基本性质，生物体已经进化出令人惊讶的不同策略，控制复制开始。在这里，我们讨论的共同点和差异，在复制起点组织和识别的三个领域的生活。
In all kingdoms of life, is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by prior to cell division to ensure each daughter cell receives the full complement of . DNA synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, organisms have evolved surprisingly divergent strategies that control replication onset. Here, we discuss commonalities and differences in replication origin organization and recognition in the three domains of life.