A GENETIC-LINKAGE MAP OF THE HUMAN GENOME
A GENETIC-LINKAGE MAP OF THE HUMAN GENOME
复制标题
DOI：
10.1016/0092-8674(87)90158-9
复制
发表时间：
1987-10-23
期刊：
影响因子：
64.5
通讯作者：
ABRAHAMSON, J
中科院分区：
文献类型：
--
作者：
DONISKELLER, H;GREEN, P;ABRAHAMSON, J
我们报告的人类基因组的连锁图谱的构建，遗传模式的基础上的403个多态性位点，包括393个RFLP，在一个面板的DNA从21个三代家庭。通过结合数学连锁分析和物理定位的选择克隆，有可能安排这些基因座到连锁群代表23个人类染色体。我们估计，该连锁图谱与人类基因组中至少95%的DNA可检测地连锁。
We report the construction of a linkage map of the human genome, based on the pattern of inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three-generation families. By a combination of mathematical linkage analysis and physical location of selected clones, it was possible to arrange these loci into linkage groups representing 23 human chromosomes. We estimate that the linkage map is detectably linked to at least 95% of the DNA in the human genome.