Air flow assisted ionization for remote sampling of ambient mass spectrometry and its application
Air flow assisted ionization for remote sampling of ambient mass spectrometry and its application
复制标题
DOI：
10.1002/rcm.4920
复制
发表时间：
2011-04-01
影响因子：
2
通讯作者：
Abliz, Zeper
中科院分区：
文献类型：
--
作者：
He, Jiuming;Tang, Fei;Abliz, Zeper
环境电离方法是质谱（MS）分析的一个重要研究领域。在环境条件下，气流和大气压力显着影响离子的传输和聚焦。本文描述了气流辅助电离（AFAI）作为一种新颖且有效的环境质谱远程采样方法的设计和实现。 AFAI 受益于高抽气流量。对AFAI系统中的提取气流进行了系统研究，证明它不仅在带电液滴的有效捕获和远程传输中发挥作用，而且还促进去溶剂化和离子形成，甚至防止电离过程中的离子碎裂。此外，AFAI方法显着提高了远程采样环境MS分析的灵敏度。使用 AFAI-MS 已成功分析高极性和非极性分子，包括染料、药物样品、爆炸物、滥用药物、蛋白质和挥发性化合物。该技术在手指残留检测、大物体分析和远程实时监控方面的成功应用表明了其在各种样品尤其是大物体分析中的潜力。该技术能够与大多数带有 API 接口的商用 MS 仪器相结合，进一步增强了其广泛的适用性。版权所有 (C) 2011 John Wiley & Sons, Ltd.
Ambient ionization methods are an important research area in mass spectrometry (MS) analysis. Under ambient conditions, the gas flow and atmospheric pressure significantly affect the transfer and focusing of ions. The design and implementation of air flow assisted ionization (AFAI) as a novel and effective, remote sampling method for ambient mass spectrometry are described herein. AFAI benefits from a high extracting air flow rate. A systematic investigation of the extracting air flow in the AFAI system has been carried out, and it has been demonstrated not only that it plays a role in the effective capture and remote transport of charged droplets, but also that it promotes desolvation and ion formation, and even prevents ion fragmentation during the ionization process. Moreover, the sensitivity of remote sampling ambient MS analysis was improved significantly by the AFAI method. Highly polar and nonpolar molecules, including dyes, pharmaceutical samples, explosives, drugs of abuse, protein and volatile compounds, have been successfully analyzed using AFAI-MS. The successful application of the technique to residue detection on fingers, large object analysis and remote monitoring in real time indicates its potential for the analysis of a variety of samples, especially large objects. The ability to couple this technique with most commercially available MS instruments with an API interface further enhances its broad applicability. Copyright (C) 2011 John Wiley & Sons, Ltd.