MOLECULAR-CLONING OF CDNA-ENCODING THE 110-KDA AND 21-KDA REGULATORY SUBUNITS OF SMOOTH-MUSCLE PROTEIN PHOSPHATASE-1M
MOLECULAR-CLONING OF CDNA-ENCODING THE 110-KDA AND 21-KDA REGULATORY SUBUNITS OF SMOOTH-MUSCLE PROTEIN PHOSPHATASE-1M
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DOI：
10.1016/0014-5793(94)01231-8
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发表时间：
1994-12-12
期刊：
影响因子：
3.5
通讯作者：
COHEN, PTW
中科院分区：
文献类型：
--
作者：
CHEN, YH;CHEN, MX;COHEN, PTW
蛋白磷酸酶- 1m（平滑肌中肌球蛋白去磷酸化的主要酶）的M（110）和M（21）调控亚基的结构已经从克隆的cdna中推断出来。来自大鼠主动脉的M（110）亚基的n端包含7个锚蛋白重复序列，而来自鸡胗的M（21）亚基的c端包含一个亮氨酸拉链基序。M（110）亚基有两种不同的表达形式，它们的c端序列不同。其中一个与整个M（21）亚基高度同源。
The structures of the M(110) and M(21) regulatory subunits of protein phosphatase-1M, the major enzyme which dephosphorylates myosin in smooth muscle, have been deduced from cloned cDNAs. The N-terminus of the M(110) subunit from rat aorta contains seven ankyrin repeats, while the C-terminus of the M(21) subunit from chicken gizzard contains a leucine zipper motif. The M(110) subunit is expressed in two different forms which differ in their C-terminal sequences. One of these is highly homologous to the whole of the M(21) subunit.