Increased plasma HB-EGF associated with obesity and coronary artery disease
Increased plasma HB-EGF associated with obesity and coronary artery disease
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DOI：
10.1006/bbrc.2002.6720
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发表时间：
2002-04-05
影响因子：
3.1
通讯作者：
Matsuzawa, Y
中科院分区：
文献类型：
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作者：
Matsumoto, S;Kishida, K;Matsuzawa, Y
肥胖受试者与血管疾病更相关的机制尚不清楚。我们报道了脂肪组织产生和分泌许多生物活性分子，概念为脂肪细胞因子。肝素结合表皮生长因子（Heparin-binding epidermal growth factor， EGF）样生长因子（HB-EGF）是由血管巨噬细胞和平滑肌细胞局部产生的，被认为可以诱导血管平滑肌细胞的迁移和增殖。目前的研究表明：(1)HB-EGF mRNA在人类脂肪组织中大量表达；(2)肥胖小鼠脂肪组织中HB-EGF mRNA升高；(3)人血浆HB-EGF水平与脂肪积累平行升高；(4)冠心病患者血浆HB-EGF水平较高，与脂肪积累相关。这些结果表明，积累脂肪引起的血浆HB-EGF增加导致肥胖患者血管疾病的发生率升高，表明HB-EGF是直接连接脂肪血管轴的脂肪细胞因子。(C) 2002 Elsevier Science （USA）。
The mechanism by which the obese subjects are more associated with vascular disease remains unclear. We reported that the adipose tissues produce and secrete many bioactive molecules, conceptualized as adipocytokines. Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), produced locally by vascular macrophages and smooth muscle cells, has been suggested to induce the migration and proliferation of vascular smooth muscle cells. The current study reveals that (1) HB-EGF mRNA is abundantly expressed in human adipose tissue, (2) HB-EGF mRNA increases in the fat tissues of obese mice, (3) plasma HB-EGF levels increase in parallel with fat accumulation in human, and (4) the subjects with coronary artery disease have higher plasma HB-EGF levels, associated with fat accumulation. These results suggest that increased plasma HB-EGF derived from the accumulated fat contributes to the higher incidence of vascular disease in obesity, proposing HB-EGF as an adipocytokine directly linking adipovascular axis. (C) 2002 Elsevier Science (USA).