Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis
Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis
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DOI：
10.1136/thx.2008.101469
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发表时间：
2009-07-01
期刊：
影响因子：
10
通讯作者：
Leonardi-Bee, J. A.
中科院分区：
文献类型：
--
作者：
Allen, S.;Britton, J. R.;Leonardi-Bee, J. A.
背景：流行病学研究表明，膳食中维生素A、C和E的摄入可能与哮喘的发生有关。根据MOOSE指南进行系统回顾和荟萃分析，以确定维生素A、C和E（以饮食摄入量或血清水平测量）是否与哮喘相关。MEDLINE、EMBASE、CINAHL、CAB摘要和AMED（截至2007年11月），检索会议记录和论文参考书目，以确定哮喘研究，与维生素A、C和E的摄入量和血清浓度相关的喘息或气道反应性。结果：共纳入40篇文献，均数比（OR）或均数差（MD）及95%可信区间（CI）采用随机效应模型进行估计。哮喘患者的膳食维生素A摄入量显著低于非哮喘患者（MD 2182 μ g/天，95% CI -288至-75; 3项研究），重度哮喘患者的膳食维生素A摄入量显著低于轻度哮喘患者（MD -344 μ g/天; 2项研究）。较低的分位数饮食摄入量（OR 1.12，95%CI 1.04至1.21; 9项研究）和血清维生素C水平也与哮喘发病率增加有关。维生素E摄入量通常与哮喘状态无关，但严重哮喘患者的维生素E摄入量显著低于轻度哮喘患者（MD-1.20 μ g/d，95%CI-2.3至-0.1; 2项研究）。结论：相对较低的维生素A和C饮食摄入量与哮喘和喘息的统计学显著增加相关。维生素E摄入量似乎与哮喘状态无关。
Background: Epidemiological studies suggest that dietary intake of vitamins A, C and E may be associated with the occurrence of asthma. A systematic review and meta-analysis was conducted in accordance with MOOSE guidelines to determine whether vitamins A, C and E, measured as dietary intakes or serum levels, are associated with asthma.Methods: MEDLINE, EMBASE, CINAHL, CAB abstracts and AMED (up to November 2007), conference proceedings and bibliographies of papers were searched to identify studies of asthma, wheeze or airway responsiveness in relation to intakes and serum concentrations of vitamins A, C and E. Pooled odds ratios (OR) or mean differences (MD) with 95% confidence intervals (CI) were estimated using random effects models.Results: A total of 40 studies were included. Dietary vitamin A intake was significantly lower in people with asthma than in those without asthma (MD 2182 mu g/day, 95% CI -288 to -75; 3 studies) and in people with severe asthma than in those with mild asthma (MD -344 mu g/day; 2 studies). Lower quantile dietary intakes (OR 1.12, 95% CI 1.04 to 1.21; 9 studies) and serum levels of vitamin C were also associated with an increased odds of asthma. Vitamin E intake was generally unrelated to asthma status but was significantly lower in severe asthma than in mild asthma (MD -1.20 mu g/day, 95% CI -2.3 to -0.1; 2 studies).Conclusions: Relatively low dietary intakes of vitamins A and C are associated with statistically significant increased odds of asthma and wheeze. Vitamin E intake does not appear to be related to asthma status.