AIDS epidemic trends after the introduction of antiretroviral therapy in Brazil
AIDS epidemic trends after the introduction of antiretroviral therapy in Brazil
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DOI：
10.1590/s0034-89102006000800003
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发表时间：
2006-04-01
期刊：
影响因子：
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通讯作者：
Brito, Ana Maria de
中科院分区：
文献类型：
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作者：
Dourado, Inês;Veras, Maria Amélia de S M;Brito, Ana Maria de
目的：从1996年开始，抗逆转录病毒（ARV）治疗的普及改变了巴西艾滋病毒/艾滋病的流行情况。本研究的目的是审查艾滋病毒/艾滋病流行的流行病学在Brazil.METHODS：指标的时间趋势，从1990年至2003年使用卫生部的数据库开发的巴西地区。指数回归模型调整到1990-1996年的趋势被用来估计预期值为整个period.RESULTS：艾滋病住院的比例在研究期间没有改变，但有一个使用抗逆转录病毒治疗的住院减少。从1997年到2003年，接受抗逆转录病毒治疗的人数增加了2.7。截至1995年，所有区域的艾滋病毒/艾滋病发病率和死亡率都有所上升。自1996年以来，死亡率逐步下降，而发病率则有所上升。在所有地区，除了在北方地区，预期的发病率已大于观察到的，在过去几年中，但这些差异仅在东南部和中西部regions.CONCLUSIONS统计显着：观察到的趋势可以解释在巴西，这对艾滋病毒/艾滋病死亡率有显着影响的抗逆转录病毒治疗的普及。但其他因素，如流行病的年份、预防行动、对艾滋病毒/艾滋病的了解、受教育年限，也需要考虑。
OBJECTIVE: Universal access to antiretroviral (ARV) therapy starting from 1996 has changed HIV/AIDS epidemic profile in Brazil. The objective of this study was to review the epidemiology of HIV/AIDS epidemic in Brazil.METHODS: Indicators of temporal trends were developed for Brazilian regions from 1990 to 2003 using the Ministry of Health's databases. Exponential regression models adjusted to the 1990-1996 trends were used to estimate expected values for the entire period.RESULTS: The proportion of AIDS hospitalizations has not changed over the study period but there was a decrease in hospitalizations among those using ARV therapy. There was a 2.7 growth in those receiving ARV therapy from 1997 to 2003. HIV/AIDS incidence and mortality rates rose up to 1995 in all regions. From 1996, there has been a gradual reduction in mortality rates while incidence rates have increased. In all regions, except in the Northern region, expected incidence rates have been greater than the observed ones in the last years but these differences were statistically significant only in the Southeastern and Midwestern regions.CONCLUSIONS: The observed trend can be explained by universal access to ARV therapy in Brazil, which had a significant impact on HIV/AIDS mortality. But other factors, such as years of epidemic, prevention actions, knowledge on HIV/AIDS, years of schooling, need to be considered as well.