The delivery of intensity modulated radiotherapy to the breast using multiple static fields
The delivery of intensity modulated radiotherapy to the breast using multiple static fields
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DOI：
10.1016/s0167-8140(00)00263-2
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发表时间：
2000-10-01
影响因子：
5.7
通讯作者：
Yarnold, JR
中科院分区：
文献类型：
--
作者：
Evans, PM;Donovan, EM;Yarnold, JR
背景和目的：开发一种使用多叶准直器（MLC）对切向乳腺野进行调强放射治疗（IMRT）的方法，使用MLC提供一组多个静态野（MSF）。材料和方法：使用电子射野成像设备（EPID）来获得内侧和外侧切向乳腺野的厚度图。这些 IMRT 分娩旨在将乳房体积最小化至规定剂量的 105% 以上。交付是通过一组低剂量成形辐射增强的通用楔形光束。该方法的剂量测定和计划质量保证与标准、楔形治疗和使用物理补偿器的相应治疗进行了比较。提出了进行 MSF 治疗的几种选择。结果：发现 MSF 技术优于标准技术（P 值 = 0.002），并且与补偿技术相当。两种 IMRT 方法均将乳房体积减少到超过 105% 剂量，从平均乳房总体积的 12.0% 减少到接近乳房总体积的 2.8%。结论：这种 MSF 方法可用于显着减少切向乳房照射中的高剂量体积。这可能会产生长期副作用，尤其是美容。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
Background and purpose: To develop a method of using a multileaf collimator (MLC) to deliver intensity modulated radiotherapy (IMRT) for tangential breast fields, using an MLC to deliver a set of multiple static fields (MSFs).Materials and methods: An electronic portal imaging device (EPID) is used to obtain thickness maps of medial and lateral tangential breast fields. From these IMRT deliveries are designed to minimize the volume of breast above 105% of prescribed dose. The deliveries are universally-wedged beams augmented with a set of low dose shaped irradiations. Dosimetric and planning QA of this method has been compared with the standard, wedged treatment and the corresponding treatment using physical compensators. Several options for delivering the MSF treatment are presented.Results: The MSF technique was found to be superior to the standard technique (P value = 0.002) and comparable with the compensated technique. Both IMRT methods reduced the volume of breast above 105% dose from a mean value of 12.0% of the total breast volume to similar to2.8% of the total breast volume.Conclusions: This MSF method may be used to reduce the high dose volume in tangential breast irradiation significantly. This may have consequences for long-term side effects, particularly cosmesis. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.