Association of serum cystatin C with white matter abnormalities in patients with amnestic mild cognitive impairment
Association of serum cystatin C with white matter abnormalities in patients with amnestic mild cognitive impairment
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DOI：
10.1111/ggi.13767
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发表时间：
2019-09-05
影响因子：
3.3
通讯作者：
Hanyu, Haruo
中科院分区：
文献类型：
--
作者：
Hirao, Kentaro;Yamashita, Fumio;Hanyu, Haruo
目的MRI上的白色高信号（WMH）是轻度认知功能障碍（MCI）向阿尔茨海默病（AD）转化的危险因素，但其原因尚不清楚。因此，在本研究中，我们调查了WMH体积与认知功能，血液中各种分子水平以及遗忘型MCI患者生活方式相关疾病的存在之间的关联。方法对38例遗忘型MCI患者和10例正常对照者的原始资料进行分析。采用3D Slicer软件测量T2液体衰减反转恢复时脑室周围高信号（PVH）和深部WMH（DWMH）的体积;以及PVH/DWMH体积与认知功能、血液中分子水平（如胱抑素C [CysC]，25-羟基维生素D和同型半胱氨酸）和生活方式相关疾病的存在（如高血压、高脂血症、糖尿病）进行分析。结果MCI组PVH体积/颅内体积比与Trail Making Test-A/B评分和CysC水平相关，与CysC水平相关，与DWMH体积/颅内体积比无关。结论PVH体积与额叶功能障碍，特别是注意和执行功能障碍密切相关。血清CysC水平与PVH体积相关，提示CysC可能是确定遗忘型MCI患者白色异常治疗策略的有用指标。Geriatr Gerontol Int 2019;中心点中心点：中心点中心点-中心点中心点。
Aim White matter hyperintensities (WMH) on MRI have been reported to be a risk factor for the conversion from mild cognitive impairment (MCI) to Alzheimer's disease, although the reason remains unclear. In the present study, we hence investigated the associations between WMH volumes and cognitive function, blood levels of various molecules, and the presence of lifestyle-associated diseases in patients with amnestic MCI. Methods The initial data of 38 patients with amnestic MCI and 10 normal control individuals were analyzed. The volumes of periventricular hyperintensities (PVH) and deep WMH (DWMH) were measured on T2 fluid-attenuated inversion recovery using the imaging software, 3D Slicer; and the association between PVH/DWMH volumes and cognitive function, blood levels of molecules (such as cystatin C [CysC], 25-hydroxyvitamin D and homocysteine) and the presence of lifestyle-associated diseases (such as hypertension, hyperlipidemia and diabetes mellitus) were analyzed. Results In the MCI group, the PVH volume : intracranial volume ratio significantly correlated with Trail Making Test-A/B scores and CysC level by Pearson's analysis, and the PVH volume : intracranial volume ratio significantly correlated with only CysC levels, whereas the DWMH volume : intracranial volume ratio did not correlate with any items at all by linear multiple regression analysis. Conclusions PVH volume was closely associated with frontal lobe dysfunction, particularly with attention and executive dysfunction. Serum CysC level was associated with PVH volume, which suggests that CysC might be a useful marker for determining treatment strategies for white matter abnormalities in amnestic MCI. Geriatr Gerontol Int 2019; center dot center dot: center dot center dot-center dot center dot.