Erythropoietin production in cultures of goat renal glomeruli.
Erythropoietin production in cultures of goat renal glomeruli.
复制标题
山羊肾小球培养物中促红细胞生成素的产生。
DOI：
--
复制
发表时间：
1972
影响因子：
11.1
通讯作者：
E. Zanjani
中科院分区：
文献类型：
--
作者：
H. Burlington;E. Cronkite;U. Reincke;E. Zanjani
培养开始与分离的山羊肾肾小球产生红细胞生成素超过7个月的时间。生产似乎取决于更换培养基之间的最小间隔约30天。区分红细胞生成素、肾激活剂和血清底物的实验支持释放到长期肾小球培养物的介质中的因子是红细胞生成素本身的结论。该系统为研究促红细胞生成素生产的调节提供了有前途的机会，并可能被开发为大量激素的来源。
Cultures initiated with isolated goat-kidney glomeruli produce erythropoietin over periods of 7 months. Production seems dependent upon a minimum interval of about 30 days between changes of medium. Experiments distinguishing between erythropoietin, renal activator, and serum substrate support the conclusion that the factor released to the medium of long-term glomerular cultures is erythropoietin itself. The system offers promising opportunities for studying regulation of erythropoietin production, and possibly could be developed as a source of significant quantities of the hormone.