VARIATION IN PLANE OF CELL CLEAVAGE DURING PROCESS OF STRATIDICATION IN MOUSE EPIDERMIS
VARIATION IN PLANE OF CELL CLEAVAGE DURING PROCESS OF STRATIDICATION IN MOUSE EPIDERMIS
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DOI：
10.1111/j.1365-2133.1970.tb12437.x
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发表时间：
1970-01-01
影响因子：
10.3
通讯作者：
SMART, IHM
中科院分区：
文献类型：
--
作者：
SMART, IHM
总结：从胚胎开始分层到纳塔尔后32天，在发育中的小鼠表皮中记录有丝分裂像的位置和方向。研究发现，在单层阶段，有丝分裂像的方向是产生一个与上皮表面成直角的分裂平面，从而产生并排排列的子细胞，并且从分层开始直到角化开始，大约75-85%的有丝分裂像在基底层中被定向为产生水平分裂，留下一个子细胞在基底层上，另一个子细胞在上面的层中。这与基底上层中许多有丝分裂像的方向形成对比，其中75-85%垂直分配。在纳塔尔后32天的分层后期，基底层外的有丝分裂像逐渐下降，基底层中的有丝分裂方向恢复到垂直位置。得出的结论是，在开始的分层表面细胞招募从表面的子细胞水平分裂的基底细胞，而在建立角化上皮这些细胞起源于向上迁移的间期基底细胞。
SUMMARY.The location and orientation of mitotic figures were recorded in the developing mouse epidermis from the initiation of stratification in the embryo to 32 days of post‐natal age. It was found that in the single‐layered stage mitotic figures were orientated to give a plane of cleavage at right angles to the epithelial surface to give daughter cells lying side by side, and that from the onset of stratification until the beginning of keratinization some 75–85% of mitotic figures in the basal layer were orientated to give horizontal cleavage, leaving one daughter cell on the basal layer and the other in the layer above. This contrasted with the orientation of the numerous mitotic figures in the supra‐basal layer, where 75–85% were partitioning vertically. In the later stages of stratification up to 32 days of post‐natal life, there was a progressive decline of mitotic figures outside the basal layer and a return of mitotic orientation in the basal layer to the vertical position. It was concluded that during the initiation of stratification superficial cells are recruited from the superficial daughter cells of horizontally cleaving basal cells whereas in the established keratinized epithelium these cells originate from upward migration of interphase basal cells.