Relationship of interictal epileptiform discharges to sleep depth in partial epilepsy
Relationship of interictal epileptiform discharges to sleep depth in partial epilepsy
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DOI：
10.1016/s0013-4694(96)96028-9
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Aldrich, MS
中科院分区：
文献类型：
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作者：
Malow, BA;Kushwaha, A;Aldrich, MS
非快速眼动 (NREM) 睡眠会激活许多癫痫综合征的发作间期癫痫样放电（尖峰）。为了更准确地定义这种现象，我们研究了 8 名部分性癫痫患者的峰值与绝对对数增量功率 (LDP) 的关系，LDP 是睡眠深度的连续测量方法。 LDP 在视觉评分睡眠阶段之间存在显着差异。对主要尖峰焦点对侧的中央枕叶通道（左侧颞焦点为 C4-O2，右侧颞焦点为 C3-O1）进行了与 LDP 相关的尖峰发生的 Logistic 回归分析。在 NREM 睡眠中，峰值更有可能发生：(1) LDP 水平较高，(2) LDP 上升肢，(3) LDP 上升更快。 NREM 睡眠中每分钟的峰值频率比快速眼动 (REM) 睡眠中高 4.6 倍，并且随着睡眠开始时间的延长而减少。然而，当分析中控制 LDP 的影响时，快速眼动睡眠阶段或时间对尖峰发生没有显着影响。只有 1% 的峰值发生在觉醒后 10 天内。这些发现表明，NREM 睡眠加深的过程可能有助于部分性癫痫的尖峰激活。 (C) 1997 爱思唯尔科学爱尔兰有限公司
Non-rapid eye movement (NREM) sleep activates interictal epileptiform discharges (spikes) in many epileptic syndromes. To define this phenomenon more precisely, we studied the relationship of spikes to absolute log delta power (LDP), a continuous measure of sleep depth, in 8 patients with partial epilepsy. LDP differed significantly across visually scored sleep stages. Logistic regression analyses of spike occurrence in relation to LDP were carried out on the central-occipital channel contralateral to the dominant spike focus (C4-O2 for left and C3-O1 for right temporal focus). Within NREM sleep, spikes were more likely to occur: (1) at higher levels of LDP, (2) on the ascending limb of LDP, and (3) with more rapid rises in LDP. Spike frequency per minute was 4.6 times higher in NREM than in rapid-eye movement (REM) sleep and diminished with time from sleep onset. When the effect of LDP was controlled for in the analysis, however, there was no significant effect of REM sleep stage or time on spike occurrence. Only 1% of spikes occurred within 10 a of an arousal. These findings suggest that processes underlying the deepening of NREM sleep may contribute to spike activation in partial epilepsy. (C) 1997 Elsevier Science Ireland Ltd.