Alcohol use disorder and divorce: evidence for a genetic correlation in a population-based Swedish sample.
Alcohol use disorder and divorce: evidence for a genetic correlation in a population-based Swedish sample.
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DOI：
10.1111/add.13719
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Kendler KS
中科院分区：
文献类型：
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作者：
Salvatore JE;Larsson Lönn S;Sundquist J;Lichtenstein P;Sundquist K;Kendler KS
我们测试了酒精使用障碍（AUD）与离婚之间的关联；估计遗传和环境对离婚的影响；估计遗传和环境影响在多大程度上解释了 AUD 和离婚之间的协方差；并估计澳元与离婚之间潜在的遗传和环境相关性。我们测试了这些影响的性别差异。我们通过瑞典国家登记册中的澳元和离婚信息确定了双胞胎和兄弟姐妹。我们使用四面体描述了澳元与离婚之间的关联；并使用双胞胎和兄弟姐妹模型来估计遗传和环境对离婚的影响、AUD 与离婚之间的协方差以及 AUD 与离婚之间的潜在遗传和环境相关性。瑞典。 670,836 人（53% 男性）出生于 1940 年至 1965 年。澳元和离婚的终身衡量标准。 AUD 和离婚密切相关（估计值 [95% CI]：男性：rtet = +0.44 [0.43, 0.45]；女性 rtet = +0.37 [0.36, 0.38]）。遗传因素在离婚差异中所占比例不大（男性：21.3% [7.6, 28.5]；女性：31.0% [18.8, 37.1]）。 AUD与离婚之间的协方差主要由遗传因素决定（男性：52.0% [48.8, 67.9]；女性：53.74% [17.6, 54.5]），其次是非共享环境因素（男性：45.0% [37.5, 54.9]；女性：41.6% [40.3, 60.2]）。共同的环境因素在协方差中所占的比例可以忽略不计（男性：3.0% [−3.0, 13.5]；女性：4.75%，[0.0, 6.6]。）AUD 与离婚的遗传相关性很高（男性：rA = +0.76 [0.53, 0.90]；女性 +0.52 [0.24， 0.67]）。非共享环境相关性不大（男性：rE = +0.32 [0.31, 0.40]；女性：+0.27 [0.27, 0.36]）。离婚和酒精使用障碍（AUD）在瑞典人群中密切相关，离婚的遗传性与之前的研究一致。 AUD 和离婚之间的协变是由重叠的遗传因素和非共享的环境因素造成的。 AUD 与离婚之间的潜在遗传和非共享环境相关性为高和中度。
We tested the association between alcohol use disorder (AUD) and divorce; estimated the genetic and environmental influences on divorce; estimated how much genetic and environmental influences accounted for covariance between AUD and divorce; and estimated latent genetic and environmental correlations between AUD and divorce. We tested sex differences in these effects. We identified twin and sibling pairs with AUD and divorce information in Swedish national registers. We described the association between AUD and divorce using tetrachorics; and used twin and sibling models to estimate genetic and environmental influences on divorce, on the covariance between AUD and divorce, and the latent genetic and environmental correlations between AUD and divorce. Sweden. 670,836 individuals (53% male) born 1940–1965. Lifetime measures of AUD and divorce. AUD and divorce were strongly related (estimates [95% CIs]: males: rtet = +0.44 [0.43, 0.45]; females rtet = +0.37 [0.36, 0.38]). Genetic factors accounted for a modest proportion of the variance in divorce (males: 21.3% [7.6, 28.5]; females: 31.0% [18.8, 37.1]). Genetic factors accounted for most of the covariance between AUD and divorce (males: 52.0% [48.8, 67.9]; females: 53.74% [17.6, 54.5]), followed by nonshared environmental factors (males: 45.0% [37.5, 54.9]; females: 41.6% [40.3, 60.2]). Shared environmental factors accounted for a negligible proportion of the covariance (males: 3.0% [−3.0, 13.5]; females: 4.75%, [0.0, 6.6].) The AUD-divorce genetic correlations were high (males: rA = +0.76 [0.53, 0.90]; females +0.52 [0.24, 0.67]). The nonshared environmental correlations were modest (males: rE = +0.32 [0.31, 0.40]; females: +0.27 [0.27, 0.36]). Divorce and alcohol use disorder (AUD) are strongly correlated in the Swedish population, and the heritability of divorce is consistent with previous studies. Covariation between AUD and divorce results from overlapping genetic and nonshared environmental factors. Latent genetic and nonshared environmental correlations for AUD and divorce are high and moderate.