The Homer family proteins.
The Homer family proteins.
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DOI：
10.1186/gb-2007-8-2-206
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发表时间：
2007
期刊：
影响因子：
12.3
通讯作者：
Furuichi T
中科院分区：
文献类型：
--
作者：
Shiraishi-Yamaguchi Y;Furuichi T
Homer家族的蛋白质充当许多突触后密度蛋白的适配器。它们被选择性地剪接成短的和长的形式;长的形式可能充当蛋白质信号复合物，而短的形式可能通过与靶蛋白的竞争性结合来破坏荷马复合物。Homer家族的衔接蛋白由哺乳动物中的三个成员组成，并且在其他动物中也已知同源物，但在其他地方没有。它们主要定位于哺乳动物神经元的突触后密度，并作为许多突触后密度蛋白的接头蛋白。由于选择性剪接，每个成员都有几个变体，主要分为长型和短型。长Homer形式组成型表达并由两个主要结构域组成：氨基末端靶结合结构域，其包括使能/血管舒张剂刺激的磷蛋白（Ena/VASP）同源1（EVH 1）结构域，和羧基末端自组装结构域，其含有卷曲螺旋结构和亮氨酸拉链基序。长荷马蛋白的多聚体，通过其羧基末端结构域偶联，被认为与其他突触后密度蛋白形成蛋白质簇，这些蛋白质簇通过氨基末端结构域结合。这种Homer介导的聚类可能调节或促进靶蛋白之间的信号转导或串扰。短的Homer形式缺乏羧基末端结构域;它们以活性依赖性的方式表达为立即早期基因产物，可能通过与靶蛋白的竞争性结合破坏Homer簇。Homer蛋白还参与多种非神经生理功能。
The Homer family of proteins act as adapters for many postsynaptic density proteins. They are alternatively spliced into short and long forms; the long forms probably act as protein signaling complexes, whereas short forms might disrupt Homer complexes by competitive binding to target proteins. The Homer family of adaptor proteins consists of three members in mammals, and homologs are also known in other animals but not elsewhere. They are predominantly localized at the postsynaptic density in mammalian neurons and act as adaptor proteins for many postsynaptic density proteins. As a result of alternative splicing each member has several variants, which are classified primarily into the long and short forms. The long Homer forms are constitutively expressed and consist of two major domains: the amino-terminal target-binding domain, which includes an Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1 (EVH1) domain, and the carboxy-terminal self-assembly domain containing a coiled-coil structure and leucine zipper motif. Multimers of long Homer proteins, coupled through their carboxy-terminal domains, are thought to form protein clusters with other postsynaptic density proteins, which are bound through the amino-terminal domains. Such Homer-mediated clustering probably regulates or facilitates signal transduction or cross-talk between target proteins. The short Homer forms lack the carboxy-terminal domain; they are expressed in an activity-dependent manner as immediate-early gene products, possibly disrupting Homer clusters by competitive binding to target proteins. Homer proteins are also involved in diverse non-neural physiological functions.
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影响因子：
64.8
作者：
Ango, F;Prézeau, L;Fagni, L
通讯作者：
Fagni, L
影响因子：
20.3
作者：
Ishiguro, K;Xavier, R
通讯作者：
Xavier, R
影响因子：
3.5
作者：
Ango, F;Robbe, D;Fagni, L
通讯作者：
Fagni, L
DOI：
10.1016/j.molbrainres.2003.07.005
发表时间：
2003-10-21
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Kato, A;Fukazawa, Y;Sugiyama, H
通讯作者：
Sugiyama, H
影响因子：
64.8
作者：
Brakeman, PR;Lanahan, AA;Worley, PF
通讯作者：
Worley, PF