Partition of Xenon and Iodoantipyrine among Erythrocytes, Plasma, and Myocardium
Partition of Xenon and Iodoantipyrine among Erythrocytes, Plasma, and Myocardium
复制标题
氙和碘安替比林在红细胞、血浆和心肌中的分配
DOI：
10.1161/01.res.40.5.497
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发表时间：
1977
影响因子：
20.1
通讯作者：
S. Chien
中科院分区：
文献类型：
--
作者：
R. Carlin;S. Chien
建立了一种在体外无气-液界面直接测定红细胞和血浆中133Xe分布的新方法；原位观察133Xe和131l-碘安替比林在犬血液和心肌间的分配情况。37℃时，人血133Xe （&lgr;cpX，单位：ml/ml）的红细胞-血浆分配系数为2.27±0.07（平均±SD），狗血为3.31±0.06。人血131l-碘安替比林的红细胞分配系数（&lgr;cpI, ml/ml）为0.75±0.04，犬血为0.97±0.03。&lgr;cpX和&lgr；经戊巴比妥钠（30mg /kg）静脉给药后，Cp1无明显变化。dgr;狗血cpX与温度成反比；cpld随温度变化不大。血-左心室分割系数133Xe （&Dgr;btx）。校正残留血液)与红细胞体积分数(H)直接变化：&Dgr；bix= 1.32 + 2.00 h， iiodoanitpyrine的血-左心室分配系数随h变化不显著，结果支持该指标在红细胞、血浆和心肌间存在三室分配的概念。133Xe和131i -碘安替比林左心室红细胞比压无关血浆组织分配系数平均值（±SD）分别为1.08±0.16和1.54±0.20 g/ml。
A new method was developed for determining directly the distribution of 133Xe between red cells and plasma in vitro without an air-fluid interface; the partitioning of 133Xe and 131l-iodoantipyrine between blood and myocardium was investigated in the dog in situ. The red cell-plasma partition coefficient for 133Xe (&lgr;cpX, unit: ml/ml) at 37°C was 2.27 ± 0.07 (mean ± SD) for human blood and 3.31 ± 0.06 for dog blood. The red cellplasma partition coefficient for 131l-iodoantipyrine (&lgr;cpI, ml/ml) was 0.75 ± 0.04 for human blood and 0.97 ± 0.03 for dog blood. &lgr;cpX and &lgr;cp1, did not change significantly after the intravenous administration of sodium pentobarbital (30 mg/kg) into the dog. &Dgr;cpX of dog blood varied inversely with temperature, whereas &Dgr;cplshowed very little change with temperature. The blood-left ventricle partition coefficient for 133Xe (&Dgr;btx. corrected for trapped blood) varied directly with red cell volume fraction (H): &Dgr;bix= 1.32 + 2.00 H. Blood-left ventricle partition coefficient for 131Iiodoanitpyrine did not vary significantly with H. The results support the concept of a three-compartment partition of the indicator among erythrocytes, plasma, and myocardium. The mean values (± SD) of the hematocrit-independent plasma-tissue partition coefficients in the left ventricle for 133Xe and 131I-iodoantipyrine were 1.08 ± 0.16 and 1.54 ± 0.20 g/ml, respectively.