ANTIBODIES TO EPSTEIN-BARR VIRUS-DETERMINED ANTIGENS IN NORMAL SUBJECTS AND IN PATIENTS WITH SEROPOSITIVE RHEUMATOID-ARTHRITIS
ANTIBODIES TO EPSTEIN-BARR VIRUS-DETERMINED ANTIGENS IN NORMAL SUBJECTS AND IN PATIENTS WITH SEROPOSITIVE RHEUMATOID-ARTHRITIS
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DOI：
10.1073/pnas.76.11.5825
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
VAUGHAN, JH
中科院分区：
文献类型：
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作者：
CATALANO, MA;CARSON, DA;VAUGHAN, JH
血清阳性类风湿性关节炎 (RA) 患者的针对核抗原 [Ag]（RA 核 Ag）的沉淀抗体 [Ab] 的频率增加，在感染 Epstein-Barr 病毒 [EBV] 的人 B [骨髓源性] 淋巴母细胞系中检测到。血清阳性 RA 患者的抗体滴度特别升高，为另一种特征更明确的 EBV 相关 B 细胞抗原，即 EBV 核抗原，可通过抗补体免疫荧光检测到。这 2 种抗体的效价不受血清中类风湿因子吸收的影响。 RA 患者的 EBV 衣壳抗原或其他 3 种人类疱疹病毒（1 型单纯疱疹病毒、水痘带状疱疹病毒和巨细胞病毒）的滴度或抗体没有升高。在正常个体和 RA 患者中，RA 核抗原抗体的存在与 EBV 核抗原抗体滴度之间存在显着相关性。具有RA核抗原抗体的正常受试者的EBV核抗原抗体滴度与RA患者相当，并且显着高于缺乏RA核抗原抗体的正常受试者。血清阳性 RA 患者可能来自较大人群，对 EBV 测定的 B 淋巴细胞核 Ag 的免疫反应增强。
Patients with seropositive rheumatoid arthritis (RA) have an increased frequency of precipitating antibody [Ab] against a nuclear antigen [Ag], the RA nuclear Ag, detected in human B [bone marrow-derived] lymphoblastoid cell lines infected by Epstein-Barr virus [EBV]. Patients with seropositive RA have specifically elevated titers of Ab to another, better-characterized EBV-associated B cell Ag, the EBV nuclear Ag, which is detected by anti-complement immunofluorescence. Titers of these 2 Ab were not affected by absorption of rheumatoid factor from serum. Patients with RA did not have elevated titers or Ab against the EBV capsid Ag or to 3 other species of human herpesviruses: herpes simplex type 1, varicella-zoster virus and cytomegalovirus. In normal individuals and RA patients there was a significant association between the presence of Ab to RA nuclear Ag and the titers of Ab to EBV nuclear Ag. Normal subjects with Ab to RA nuclear Ag had titers of Ab to EBV nuclear Ag equivalent to those of patients with RA and significantly higher than normal subjects lacking Ab to RA nuclear Ag. Patients with sero-positive RA may derive from a larger population with enhanced immune responsiveness to B lymphocyte nuclear Ag determined by EBV.