Estimation of safe doses: critical review of the hockey stick regression method.
Estimation of safe doses: critical review of the hockey stick regression method.
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DOI：
10.1289/ehp.7932193
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发表时间：
1979-10
影响因子：
10.4
通讯作者：
Yamamoto E
中科院分区：
文献类型：
--
作者：
Yanagimoto T;Yamamoto E
曲棍球棒回归法是一种利用分段直线的回归方法，是估算安全剂量的一种简便方法。该方法直观上似乎是有用的，但需要假设存在正阈值。该假设的有效性被认为难以证明。在适当的剂量-反应曲线下，通过引入风险水平，给出了不基于假设的替代方法。在这里，使用概率单位模型的方法与曲棍球棒回归方法进行了比较。计算结果表明，替代方法是可取的。此外，在响应被测量为连续值的情况下的类似问题也被扩展。举例说明了SO_2与单纯性慢性支气管炎的关系、光化学氧化剂与雏鸡眼部不适的关系以及抗生素在雏鸡体内的残留。这些数据是由原作者在正阈值存在的假设下分析的。
The hockey stick regression method is a convenient method to estimate safe doses, which is a kind of regression method using segmented lines. The method seems intuitively to be useful, but needs the assumption of the existence of the positive threshold value. The validity of the assumption is considered to be difficult to be shown. The alternative methods which are not based on the assumption, are given under suitable dose-response curves by introducing a risk level. Here the method using the probit model is compared with the hockey stick regression method. Computational results suggest that the alternative method is preferable. Furthermore similar problems in the case that response is measured as a continuous value are also extended. Data exemplified are concerned with relations of SO2 to simple chronic bronchitis, relations of photochemical oxidants to eye discomfort and residual antibiotics in the lever of the chicks. These data was analyzed by the original authors under the assumption of the existence of the positive threshold values.