Impaired left ventricular systolic and diastolic function in patients with metabolic syndrome as assessed by strain and strain rate imaging
Impaired left ventricular systolic and diastolic function in patients with metabolic syndrome as assessed by strain and strain rate imaging
复制标题
通过应变和应变率成像评估代谢综合征患者左心室收缩和舒张功能受损。
DOI：
10.1016/j.diabres.2008.10.018
复制
发表时间：
2009-03-01
影响因子：
5.1
通讯作者：
Zhang, Yun
中科院分区：
文献类型：
--
作者：
Gong, Hui-ping;Tan, Hong-wei;Zhang, Yun
The present study aimed to investigate cardiac structural and functional alterations in patients with metabolic syndrome (MS) and to compare those with control subjects. Strain and strain rate (SR) imaging were preformed in 200 patients with MS and 197 normal subjects. The patients were further divided into Group 1 (with three metabolic disorders) and Group 2 (with four metabolic disorders) to elucidate the influence of different metabolic components on left ventricular (LV) functions. LV diastolic and systolic functions were determined by the mean systolic strain, SR-LVs and SR-LVe. There were no differences in LVEF among the three groups. However, the mean systolic strain, SR-LVs and SR-LVe, were significantly decreased in Group 1 and Group 2 when compared with control subjects (all P < 0.001). The mean systolic strain and SR-LVe were lower in Group 2 than Group 1 (all P < 0.05). Stepwise multiple regression analyses revealed that the W-H ratio was an independent predictor of the LV systolic function, whereas W-H ratio, HDL cholesterol and SBP were independent predictors of LV diastolic function. In summary, our results demonstrated that LV systolic and diastolic functions were impaired in patients with metabolic syndrome even if they have normal LVEF. Strain and SR imaging would be a sensitive and feasible method to detect subclinical abnormalities in those populations. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
