Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients
Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients
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DOI：
10.1007/s00380-017-1042-z
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发表时间：
2018-02-01
影响因子：
1.5
通讯作者：
Isobe, Mitsuaki
中科院分区：
文献类型：
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作者：
Aoyama, Norio;Suzuki, Jun-ichi;Isobe, Mitsuaki
高血压是一种导致生活质量下降和死亡的全身性疾病。虽然牙周炎患者患高血压的风险很高，但迄今为止提供的因果信息很少。为了阐明两者之间的关系，我们评估了伴或不伴高血压的心血管患者的牙周病理性细菌感染。研究对象为在东京医科大学医院就诊的高血压患者(n=412)和非高血压患者(n=199)。进行血液检查和牙周测量。检测3种牙周病原菌的存在情况和抗体效价。我们发现，与非高血压患者相比，患有高血压的男性患者牙周特殊致病细菌Aggregatibacter放线菌伴生菌和中间普氏杆菌的检出率较高，而女性患者的检测结果与之相当。老年男性高血压患者的平均探诊口袋深度高于非高血压患者。肥胖、血脂异常和糖尿病的发生率在两组之间显示出部分统计学差异。特殊的牙周病细菌感染可能会影响男性心血管患者的羟色胺。
Hypertension (HT) is a systemic disorder that results in the decline of quality of life and death. While patients with periodontitis are at a high risk of HT, little causal information has been provided to date. To clarify the relationship, periodontopathic bacterial infection in cardiovascular patients with or without HT was evaluated. The subjects were patients with (n = 412) or without (n = 199) HT who attended Tokyo Medical and Dental University hospital. Blood examinations and periodontal measurements were performed. Three periodontopathic bacteria existence and antibody titers were evaluated. We found that specific periodontopathic bacteria, Aggregatibacter actinomycetemcomitans and Prevotella intermedia, were highly detected in male subjects with HT compared to non-HT subjects, while they were comparable in the female patients. Mean probing pocket depth of elderly male patients with HT was higher compared to non-HT patients. The rates of obesity, dyslipidemia, and diabetes showed partial statistical difference between the two groups. Specific periodontopathic bacterial infection may affect HT in male cardiovascular patients.