PATTERNS OF GLIOSIS IN ALZHEIMERS-DISEASE AND AGING CEREBRUM
PATTERNS OF GLIOSIS IN ALZHEIMERS-DISEASE AND AGING CEREBRUM
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DOI：
10.1002/glia.440020605
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发表时间：
1989-01-01
期刊：
影响因子：
6.2
通讯作者：
MCGEER, EG
中科院分区：
文献类型：
--
作者：
BEACH, TG;WALKER, R;MCGEER, EG
在全半球冠状切片中检查了阿尔茨海默病（AD）和老化大脑中星形胶质细胞增生的分布，如胶质细胞酸性蛋白（GFAP）的免疫过氧化物酶染色所示。AD患者皮质胶质增生呈明显的层状。有两个重染色带，一个在第II-III层，另一个在第V层。正常老化的情况下，有时会显示相当大的皮质神经胶质增生，但没有具体的模式是明显的。大多数AD病例和一些正常衰老病例在灰质-白色质界面（尤其是皮质-髓交界处）显示免疫反应性星形胶质细胞肥大。皮质下灰质胶质增生在正常衰老和AD中均很常见，但两组中均无一致的模式。在年轻健康个体中染色均匀且重度的大脑深部白色物质在正常老年人和AD脑中均显示不均匀染色。在AD和老化，血管周围胶质增生是突出的整个大脑，特别是在壳核。总之，AD和老化大脑均表现出广泛的神经胶质增生：AD皮质神经胶质增生具有特定的层状模式，但似乎没有AD特异性皮质下神经胶质增生模式。
The distribution of astrocytic gliosis in Alzheimer's disease (AD) and aging cerebrum, as marked by immunoperoxidase staining for glial fibrillary acidic protein (GFAP), was examined in whole‐hemisphere coronal sections. Cortical gliosis in AD had an obvious laminar pattern. There were two heavy bands of staining, one in layers II–III and another in layer V. Normal aging cases sometimes displayed considerable cortical gliosis, but no specific patterns were apparent. Most AD cases, and some normal aging cases, displayed hypertrophy of immunoreactive astrocytes at grey matter‐white matter interfaces, especially the cortico‐medullary junction. Subcortical grey matter gliosis was common in both normal aging and AD, but there was no consistent pattern in either group. The deep cerebral white matter, which is stained evenly and heavily in young, healthy individuals, showed uneven staining in both normal elderly and AD brains. In both AD and aging, perivascular gliosis was prominent throughout the cerebrum and especially in the putamen. In conclusion, both AD and aging cerebri show extensive gliosis: AD cortical gliosis has a specific laminar pattern, but there does not appear to be an AD‐specific pattern of subcortical gliosis.