Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank.
Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank.
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DOI：
10.1371/journal.pone.0249189
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Walters JTR
中科院分区：
文献类型：
--
作者：
Dennison CA;Legge SE;Bracher-Smith M;Menzies G;Escott-Price V;Smith DJ;Doherty AR;Owen MJ;O'Donovan MC;Walters JTR
活动水平经常在精神疾病中受到影响，并且可能是疾病的核心症状。如今，技术的进步使人们能够准确地评估活动水平，但尚不清楚活动的改变是由导致精神疾病的共同风险因素（如遗传学）引起的，还是由疾病及其相关因素的后果更好地解释。我们的目的是检查精神疾病患者客观测量的身体活动，并评估精神疾病的遗传倾向对身体活动的作用。加速度计数据来自95,529名英国生物银行参与者，包括总体平均活动和每天适度活动、步行、久坐活动和睡眠的分钟数。线性回归测量了精神疾病诊断与活动水平之间的关系，以及精神疾病的多基因风险评分（PRS）与活动水平之间的关系。计算了精神疾病与不同类型活动之间的遗传相关性。与未受影响的对照组相比，被诊断为精神分裂症、双相情感障碍、抑郁症或自闭症谱系障碍（ASD）的患者总体活动减少。在没有精神疾病的个体中，总体活动水平降低与精神分裂症、抑郁症和ASD的PRS相关。ADHD PRS与整体活动增加有关。遗传相关性与PRS研究结果一致。身体活动的变化是精神疾病的一个重要特征。虽然活动水平在非常有限的程度上与精神疾病的遗传易感性相关，但精神疾病患者活动水平的实质性差异最有可能是疾病相关因素的结果。
Levels of activity are often affected in psychiatric disorders and can be core symptoms of illness. Advances in technology now allow the accurate assessment of activity levels but it remains unclear whether alterations in activity arise from shared risk factors for developing psychiatric disorders, such as genetics, or are better explained as consequences of the disorders and their associated factors. We aimed to examine objectively-measured physical activity in individuals with psychiatric disorders, and assess the role of genetic liability for psychiatric disorders on physical activity. Accelerometer data were available on 95,529 UK Biobank participants, including measures of overall mean activity and minutes per day of moderate activity, walking, sedentary activity, and sleep. Linear regressions measured associations between psychiatric diagnosis and activity levels, and polygenic risk scores (PRS) for psychiatric disorders and activity levels. Genetic correlations were calculated between psychiatric disorders and different types of activity. Having a diagnosis of schizophrenia, bipolar disorder, depression, or autism spectrum disorders (ASD) was associated with reduced overall activity compared to unaffected controls. In individuals without a psychiatric disorder, reduced overall activity levels were associated with PRS for schizophrenia, depression, and ASD. ADHD PRS was associated with increased overall activity. Genetic correlations were consistent with PRS findings. Variation in physical activity is an important feature across psychiatric disorders. Whilst levels of activity are associated with genetic liability to psychiatric disorders to a very limited extent, the substantial differences in activity levels in those with psychiatric disorders most likely arise as a consequences of disorder-related factors.
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影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
5.1
作者：
Goodwin, RD
通讯作者：
Goodwin, RD
影响因子：
30.8
作者：
Bulik-Sullivan B;Finucane HK;Anttila V;Gusev A;Day FR;Loh PR;ReproGen Consortium;Psychiatric Genomics Consortium;Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3;Duncan L;Perry JR;Patterson N;Robinson EB;Daly MJ;Price AL;Neale BM
通讯作者：
Neale BM
影响因子：
6.6
作者：
Janney, Carol A.;Fagiolini, Andrea;Swartz, Holly A.;Jakicic, John M.;Holleman, Robert G.;Richardson, Caroline R.
通讯作者：
Richardson, Caroline R.