Beta-glucan recognition by the innate immune system.
Beta-glucan recognition by the innate immune system.
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DOI：
10.1111/j.1600-065x.2009.00793.x
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发表时间：
2009-07
影响因子：
8.7
通讯作者：
Underhill DM
中科院分区：
文献类型：
--
作者：
Goodridge HS;Wolf AJ;Underhill DM
β-葡聚糖由先天免疫系统识别。这种识别在宿主防御中发挥着重要作用，并为宿主免疫反应的临床调节提供了特殊的机会。中性粒细胞、巨噬细胞和树突状细胞等表达多种受体，能够识别不同形式的β-葡聚糖。该综述探讨了目前已知的β-葡聚糖识别以及这种识别如何刺激免疫反应。特别强调Dectin-1，因为我们最了解这个关键的β-葡聚糖受体如何将识别转化为细胞内信号，刺激细胞反应，并参与协调适应性免疫反应。
β-glucans are recognized by the innate immune system. This recognition plays important roles in host defense, and presents specific opportunities for clinical modulation of the host immune response. Neutrophils, macrophages, and dendritic cells among others express several receptors capable of recognizing β-glucan in its various forms. This review explores what is currently known about β-glucan recognition and how this recognition stimulates immune responses. Special emphasis is placed on Dectin-1, since we know the most about how this key β-glucan receptor translates recognition into intracellular signaling, stimulates cellular responses, and participates in orchestrating the adaptive immune response.